The effect of prostate cancer and antianrogenic therapy on lipid peroxidation and antioxidant systems |
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Authors: | İynem Alkan Hacer Alademir Ayşe Zeynep Öbek Can Kural Ali Riza Konukoglu Dildar Akçay Tülay |
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Institution: | (1) Department of Biochemistry and Clinical Biochemistry, Cerrahpasa Faculty of Medicine, University of Istanbul, Turkey;(2) Department of Biochemistry and Clinical Biochemistry, Cerrahpasa Faculty of Medicine, University of İstanbul, Emekli Subay Evleri, 12/8 Esentepe, İstanbul, Turkey;(3) Department of Urology, Cerrahpasa Faculty of Medicine, University of İstanbul, Turkey |
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Abstract: | In living organism, excessive free radicals oroxidative damage which occur as a result of deficient antioxidant defensive
mechanisms by the effect of endogenous and exogenous factors, influences especially developmental steps of chemically induced
cancers 1, 2]. In our study, plasma malondialdehyde level (MDA) as an indicator of lipid peroxidation, erythrocyte glutathione
(GSH) level as an indicator of antioxidant state, glutathione reductase (GSH-Red), glutathione peroxidase (GSH-Px), glutathione-S-transferase
(GST) as an antioxidant enzymes and plasma vitamin E level were detected in patients with prostate cancer (21 males; age,
69.4 ± 4.8 years) before and after three months of antiandrogenic therapy with goserelin acetate as luteinizing hormone releasing
hormone (LHRH) analogue. Healthy people evaluated as a control group (20 males; age, 63.7 ± 3.9). Erythrocyte GSH levels,
the activities of GSH-Red and GSH-Px and plasma vitamin E levels were found significantly low in patients with prostate cancer
when compared with the healthy subjects (p < 0.01, p < 0.05, p ≤ 0.001 and p ≤ 0.001 respectively). Plasma MDA level and erythrocyte GST activity of patient group were significantly higher than the
levels of control group (p ≤ 0.001 and p ≤ 0.001 respectively). After antiandrogenic therapy erythrocyte GSH level, GSH-Red, GSH-Px activity and plasma vitamin E
level were found unchanged. Significant decrease in plasma MDA level and significant increase in erythrocyte GST activity
were detected in patient group (p < 0.05 and p ≤ 0.01 respectively). The study has revealed the shift in the oxidant-antioxidant balance towards oxidative state in patients
with metastatic prostate cancer. Our results showed that antiandrogenic therapy increased in GST activity, decreased in lipid
peroxidation.
This revised version was published online in August 2006 with corrections to the Cover Date. |
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Keywords: | Antiandrogenic therapy Antioxidant systems Lipid peroxidation Prostate cancer |
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