幽门螺杆菌感染与胃窦炎症病理变化的关系

目的 明确幽门螺杆菌感染（H.pylori)与胃窦炎症病理变化的关系。方法 通过胃镜活检取得胃窦组织标本，在快速尿素酶试验阳性和甲苯胺蓝染色中等阳性的病人中筛检出128例患者，其中包括慢性浅表性胃炎（CG）患者68例，十二指肠球部溃疡（DU）患者30例，胃溃疡（GU）患者30例，对患者的血清进行免疫印迹试验，检测患者的细胞毒素相关蛋白A（CagA)、空泡毒素相关蛋白A（VacA)抗体的情况。结果 胃窦炎症积分在CG、DU、GU患者胃窦炎症均表现为活动性，但是没有明显差异；CagA在所有病例中具有普遍易感性。在GU中出现8例胃窦萎缩，其中4例表现为CagA和VacA均阳性。在DU中未见胃窦萎缩。结论 H pylori相关性胃病中胃窦炎症多表现为活动性，但是没有明显差异。CagA在所有病例中具有普遍易感性，胃窦萎缩多出现在GU患者中并与CagA和VacA均阳性相关。

Relationship between infection of helicobacter pylori and pathological changes o f antrum in patients with gastroduodenal disease

Aim To investigate the relationship between pathological changes of antrum and infection of helicobacter pylori.Methods 128 cases of H.pylori infection from biopsied specimens were obtained including 30 patients with DU,68 cases with CG and 30 cases with GU.The serum anti CagA IgG and anti VacA IgG were examined by Western blot analysis.Results There was no significant difference among the patients with DU,GU and CG regarding to the degree of gastritis in the antrum( P >0. 05).All patients represented chronic and active antrum gastritis.Atrophic gastritis in antrum were represented in 7 CG and 8 GU and none in DU.4 cases of GU with antrum atrophy represented both CagA and VacA positive.The prevalence of CagA in all patients was high.Conclusions All patients represent chronic and active antrum gastritis with no significant difference.The prevalence of CagA in all patients was high.The positive of CagA and VacA may play a role in the pathogenesis of the atrophy of antrum.