Glucose oxidase incorporated collagen matrices for dermal wound repair in diabetic rat models: a biochemical study |
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| Authors: | Arul V Masilamoni J G Jesudason E P Jaji P J Inayathullah M Dicky John D G Vignesh S Jayakumar R |
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| Affiliation: | Bio-Organic and Neurochemistry Laboratory, Central Leather Research Institute, Adyar, Chennai, Tamil Nadu, India. |
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| Abstract: | Impaired wound healing in diabetes is a well-documented phenomenon. Emerging data favor the involvement of free radicals in the pathogenesis of diabetic wound healing. We investigated the beneficial role of the sustained release of reactive oxygen species (ROS) in diabetic dermal wound healing. In order to achieve the sustained delivery of ROS in the wound bed, we have incorporated glucose oxidase in the collagen matrix (GOIC), which is applied to the healing diabetic wound. Our in vitro proteolysis studies on incorporated GOIC show increased stability against the proteases in the collagen matrix. In this study, GOIC film and collagen film (CF) are used as dressing material on the wound of streptozotocin-induced diabetic rats. A significant increase in ROS (p?
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