| 绞股蓝总皂甙对自由基损伤兔主动脉舒张功能的保护作用 |
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| 引用本文： | 肖观莲,廖端芳.绞股蓝总皂甙对自由基损伤兔主动脉舒张功能的保护作用[J].中国药理学通报,1994,10(2):136-138. |
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| 作者姓名： | 肖观莲 廖端芳 |
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| 作者单位： | 衡阳医学院药理教研室 |
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| 摘 要： | 用离体兔胸主动脉环实验．观察绞股蓝总皂甙（ＧＰｓ）对电解ｋｒｅｂｓ液、黄嘌呤－黄嘌呤氧化酶及美蓝降低血管舒张功能的影响．结果表明ＧＰｓ能保护血管内皮免受自由基损伤。
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| 关 键 词： | 绞股蓝皂甙，自由基，兔胸主动脉 |
Protective effect of gypenosides on OFR-induced damage of relaxing capacity of rabbit thoracic aortae in vitro |
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| XIAO Guan-Lian,LIAO Duan-Fang, CHEN Jian-Xiong, YU Lin.Protective effect of gypenosides on OFR-induced damage of relaxing capacity of rabbit thoracic aortae in vitro[J].Chinese Pharmacological Bulletin,1994,10(2):136-138. |
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| Authors: | XIAO Guan-Lian LIAO Duan-Fang CHEN Jian-Xiong YU Lin |
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| Abstract: | In isolated rabbit thoracic aortae,we investigated the protective effect of gypenosides(GPs) on aortic damage induced by exogenous oxygen free radicals(OFR).The data showed that both electrolysed Krebs solution and xanthine-xanthine oxidase decreased the relaxation of the aortic rings induced by ACh.GPs(50mg·L-1) significantly protected the relaxing capacity of the aortic rings from OFR,so did catalase(25 mg· L-1).The protective effect was abolished by cyclooxgyenase inhibitor indomethacin(5 μmol· L-1).GPs also resisted the decrease of relaxation of the rings induced by methylene blue. |
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| Keywords: | gypenosides free radicals rabbit thoracic aortae |
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