| 大鼠主动脉α_1肾上腺素能受体激活引起Ca~（2＋）内流的特性 |
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| 引用本文： | 徐济良,关永源,陈克敏,贺华,孙家钧.大鼠主动脉α_1肾上腺素能受体激活引起Ca~（2＋）内流的特性[J].中国药理学通报,1994,10(2):101-104. |
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| 作者姓名： | 徐济良 关永源 陈克敏 贺华 孙家钧 |
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| 作者单位： | 中山医科大学药理教研室，南通医学院药理教研室 |
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| 摘 要： | 在大鼠主动脉平滑肌标本上，０．５μｍｏｌ．Ｌ－１硝苯吡啶能完全阻断由１００ｍｍｏｌ·Ｌ－１ＫＣｌ引起的血管收缩和４５Ｃａ内流；并部分抑制苯肾上腺素引起的血管收缩效应和４５Ｃａ内流；６ｍｍｏｌ·Ｌ－１普鲁卡因能完全阻断无钙Ｋｒｅｂｓ液中苯肾上腺素引起的血管收缩和４５Ｃａ外溢，且部分阻断正常Ｋｒｅｂｓ液中苯肾上腺素引起的血管收缩和４５Ｃａ内流；０．５μｍｏｌ·Ｌ－１硝苯吡啶和６ｍｍｏｌ·Ｌ－１普鲁卡因合用能阻断苯肾上腺素引起的Ｃａ２＋内流。提示：α１受体兴奋后引起的细胞外Ｃａ２＋内流可分为硝苯吡啶敏感和不敏感两部分，而后者受细胞内Ｃａ２＋释放调节。
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| 关 键 词： | Ca~（2＋）内流，Ca~（2＋）释放，α_1肾上腺素能受体血管平滑肌 |
Character of the Ca￣(2+) entry induced by activation of α_1-adrenoceptor in rat aorta |
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| XU Ji-Liang, GUAN Yong-Yuan, CHEN Ke-Ming et al.Character of the Ca￣(2+) entry induced by activation of α_1-adrenoceptor in rat aorta[J].Chinese Pharmacological Bulletin,1994,10(2):101-104. |
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| Authors: | XU Ji-Liang GUAN Yong-Yuan CHEN Ke-Ming |
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| Abstract: | In rat aorta, 0.5μmol. L-1nifedipine(Nif) completely blocked the contractile response and 45Ca influx induced by 100mmol. L-1 KCl and partially inhibited phenylephrine(PHE) -induced contractile response and 45Ca influx. 6 mmol. L-1 procaine competely blocked the contractile response and 45Ca efflux in Ca2+ free Krebs solution and partially inhibited contractile response and 45Ca influx in normal krebs solution induced by PHE. 0.5μmol. L-1 Nif plus 6 mmol. L-1 procaine completely blocked PHE-induced Ca2+ entry. These results suggest that the extracellular Ca2+ entry induced by activation of α1-adrenoceptor contains two components, sensitive to Nif and insensitive to Nif; The latter is partially regulated by intracel lular Ca2+ release. |
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| Keywords: | Ca￣(2+) influx Ca￣(2+) release α_1- adrenoceptor smooth muslce(vascular ) |
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