| 恶性脑胶质瘤术后替莫唑胺化疗联合适形放疗的疗效观察 |
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| 引用本文： | 周绍兵,刘阳晨,高飞,叶宏勋,赵莺,尹小祥.恶性脑胶质瘤术后替莫唑胺化疗联合适形放疗的疗效观察[J].陕西肿瘤医学,2008(1):34-35. |
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| 作者姓名： | 周绍兵 刘阳晨 高飞 叶宏勋 赵莺 尹小祥 |
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| 作者单位： | 江苏省泰兴市人民医院放疗科,江苏泰兴225400 |
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| 摘 要： | 目的：观察替莫唑胺联合适形放疗治疗恶性脑胶质瘤术后病例的临床疗效。方法：30例恶性脑胶质瘤术后的患者，13例行替莫唑胺联合适形放射治疗（治疗组），另17例单纯适形放射治疗（对照组）。结果：治疗组与对照组的中位生存时期为16．5个月和12．7个月；其1、2年生存率分别为76．9％、46．2％和52．9％、17．6％（P〉0．05）。结论：替莫唑胺联合适形放射治疗恶性脑胶质瘤术后有提高生存率的趋势，并发症少。
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| 关 键 词： | 恶性胶质瘤 替莫唑胺 三维适形放射治疗 |
| 文章编号： | 1672-4992-（2008）01-0034-02 |
| 收稿时间： | 2007-03-05 |
Clinical observation of temozlomide with three dimensional conformal radiotherapy in treatment of postoperative malignant glioma |
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| ZHOU Shao - bing, LIU Yang -chen, GAO Fei, YE Hong - xun, ZHAO Ying, YIN Xiao - xiang.Clinical observation of temozlomide with three dimensional conformal radiotherapy in treatment of postoperative malignant glioma[J].Shaanxi Oncology Medicine,2008(1):34-35. |
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| Authors: | ZHOU Shao - bing LIU Yang -chen GAO Fei YE Hong - xun ZHAO Ying YIN Xiao - xiang |
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| Institution: | ZHOU Shao - bing, LIU Yang -chen, GAO Fei, YE Hong - xun, ZHAO Ying, YIN Xiao - xiang( Department of Radiation Oncology, The People＇s Hospital of Taixing City,Taixing 225400 ,China.) |
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| Abstract: | Objective ：To evaluate the treatment efficacy of temozolomide（TMZ） with three dimensional conformal radiotherapy （3DCRT） for postoperative malignant glioma. Methods： Thirty postoperative patients with malignant glioma were randomized into two groups ：13 patients received TMZ and 3 DCRT （therapy group） ;17 patients received 3DCRT alone （control group）. Results： Median time to progression was 16.5 months in therapy group and 12.7 months in control group. The 1 - and 2 - year survival rates were 76.9% ,46.2% and 52.9% , 17.6% （ P 〉 0.05 ）. Conclusion： TMZ and 3DCRT for postoperative malignant glioma can improve the survival rate and decrease complications. |
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| Keywords: | malignant glioma temozolomide three dimensional conformal radiotherapy |
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