胆道闭锁Kasai术后生存分析

目的 探讨胆道闭锁患儿Kasai术后各因素对生存期的影响。方法 对51例胆道闭锁Kasai术后患儿进行回顾性分析，观察生存时间，以Kaplarr—Meier法描述生存曲线，收集可能影响预后的若干因素，运用Cox比例风险模型，进行统计分析。结果 术后胆汁引流量和是否长期随诊，积极治疗影响生存时间。全组3个月、6个月、12个月的累积生存率分别为69．15％、56．33％、32．50％，中位生存期为8个月；手术日龄越大，中位生存期越短。结论 Cox多因素分析认为：术后胆汁引流量和是否长期随访、积极治疗是影响生存时间的相关因素。手术日龄不同，生存曲线有较大变化。

Survival Analysis After Kassi Operation For Patients With Biliary Atresia

Objective To explore influence of the prognostic factors on survival period in patients with Kassi procedure in children of biliary atresia. Methods The clinical data of 51 patients with Congenital biliary atresia were analyzed retrospectively. Using Kapalarr-Meier survival curve to describe the survival rate Several factors influencing survival were collected and Cox proportional hazard model was established to statistical analysis. Results Accumulation survival rate of 3,6 and 12 months after the operation were 69.15%,56.33% and 32.50% respectively,the median survival time was 8 months. The multivariate analysis showed that the volume of biliary drainage, whether or not long-term followed-up and active effective treatment were significant prognostic factors.The older of operative age, the shorter of midian-survival time. Conclusions The volume of biliary drainage,whether or not long-term followed-up and active effective treatment have great influence on the prognosis of the biliary atresia. Survival curve have great change according to their different age at the operation.