A Modified Human Ureter Graft Tanned by a New Crosslinking Agent Polyepoxy Compound for Small Diameter Arterial Substitutions: AnExperimental Preliminary Study

The effectiveness of human ureter grafts tanned by polyepoxy compound for small diameter arterial substitution was examined in 8 carotid arteries of rabbits, followed by an observation period of either 1 month (n = 6) or 6 months (n = 2). In this model there was no evidence of rejection, aneurysm formation, or infection. The modified human ureter showed excellent patency in all cases as well as excellent function, and the histological evaluation revealed monolayer endothelial-like cells covering all of the surface of the graft as was expected. No intimal hyperplasia was demonstrated at either anastomotic site. This study suggests that our newly designed polyepoxy compound fixed human ureter could serve as a satisfactory blood conduit with good long-term patency for substitution.