Gender-dependent associations of CDKN2A/2B, KCNJ11, POLI, SLC30A8, and TCF7L2 variants with type 2 diabetes in (North African) Tunisian Arabs |
| |
| Authors: | Amira Turki Ghadeer S. Al-Zaben Moncef Khirallah Hela Marmouch Touhami Mahjoub Wassim Y. Almawi |
| |
| Affiliation: | 1. Research Unit of Biology and Genetics of Hematological and Autoimmune diseases, Faculty of Pharmacy of Monastir, University of Monastir, Monastir, Tunisia;2. Department of Medical Biochemistry, Arabian Gulf University, Manama, Bahrain;3. Department of Ophthalmology, CHU Fattouma Bourguiba, Monastir, Tunisia;4. Department of Endocrinology, CHU Fattouma Bourguiba, Monastir, Tunisia |
| |
| Abstract: | We investigated the impact of gender on T2DM association with confirmed susceptibility loci. CDKN2A/2B rs10811661, KCNJ11 rs5219, and TCF7L2 rs7903146 were associated with T2DM in females, while POLI rs488846 was associated with T2DM among males; the association of SLC30A8 rs13266634 and TCF7L2 rs4506565, rs12243326, and rs12255372 with T2DM was gender-independent. |
| |
| Keywords: | Genetic association studies Single nucleotide polymorphisms Type 2 diabetes |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
