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MiR-210: A potential therapeutic target against radiation-induced enteropathy |
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| Authors: | Saad Hamama Muhammad Zaeem Noman Pascal Gervaz Sylvie Delanian Marie-Catherine Vozenin |
| Affiliation: | 1. INSERM U-1030 “Molecular Radiotherapy”, Institut Gustave Roussy, Villejuif, France;2. LabEX LERMIT Villejuif, France;3. Université Paris Sud Paris XI, Le Kremlin Bicêtre, France;4. INSERM, U753, Laboratoire d’immunologie des Tumeurs Humaines: Interaction Effecteurs Cytotoxiques-Système Tumoral, Institut Gustave-Roussy, Villejuif, France;5. Geneva University Hospital and Medical School, Geneva, Switzerland;6. Unité de Radiopathologie, Service Oncologie-Radiothérapie, Hôpital Saint-Louis, APHP, Paris, France;g Laboratoire de RadioOncologie, Swiss Cancer Center of Lausanne, CHUV, Lausanne, Switzerland |
| Abstract: | A previously undescribed and robust miR210 overexpression is shown in intestinal samples obtained from patients with radiation enteropathy and fibrotic cultured cells. In addition, miR-210 overexpression is repressed by antifibrotic treatment combining pentoxifylline and α-tocopherol. |
| Keywords: | Anti-fibrotic treatment Radiation-induced fibrosis Radiation enteropathy microRNA miR-210 Trolox Pentoxifylline |
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