Post-chemoradiation intraoperative electron-beam radiation therapy boost in resected locally advanced rectal cancer: Long-term results focused on topographic pattern of locoregional relapse |
| |
| Authors: | Claudio V. Sole,Felipe A. Calvo,Javier Serrano,Emilio del Valle,Marcos Rodriguez,Alberto Muñ oz-Calero,Fernando Turé gano,Jose Luis Garcí a-Sabrido,Pilar Garcia-Alfonso,Isabel Peligros,Sofia Rivera,Eric Deutsch,Emilio Alvarez |
| |
| Affiliation: | 1. Department of Radiation Oncology, Instituto de Radiomedicina, Santiago, Chile;2. Department of Radiation Oncology, Institut Gustave Roussy, Villejuif, France;3. Department of Oncology, Hospital General Universitario Gregorio Marañón, Madrid, Spain;4. School of Medicine, Complutense University, Madrid, Spain;5. Service of Radiation Oncology, Hospital General Universitario Gregorio Marañón, Madrid, Spain;6. Department of Surgery, Hospital General Universitario Gregorio Marañón, Madrid, Spain;g Service of Medical Oncology, Hospital General Universitario Gregorio Marañón, Madrid, Spain;h Department of Pathology, Hospital General Universitario Gregorio Marañón, Madrid, Spain;i Instituto de Investigacion Sanitaria, Hospital General Universitario Gregorio Marañón, Madrid, Spain;j Molecular Radiotherapy Laboratory INSERM1030, Gustave Roussy Cancer Campus, Villejuif, France;k School of Medicine, Paris-Sud University, Villejuif, France |
| |
| Abstract: | BackgroundPatients with locally advanced rectal cancer (LARC) have a dismal prognosis. We investigated outcomes and risk factors for locoregional recurrence (LRR) in patients treated with preoperative chemoradiotherapy (CRT), surgery and IOERT.MethodsA total of 335 patients with LARC [?cT3 93% and/or cN+ 69%) were studied. In multivariate analyses, risk factors for LRR, IFLR and OFLR were assessed.ResultsMedian follow-up was 72.6 months (range, 4–205). In multivariate analysis distal margin distance ?10 mm [HR 2.46, p = 0.03], R1 resection [HR 5.06, p = 0.02], tumor regression grade 1–2 [HR 2.63, p = 0.05] and tumor grade 3 [HR 7.79, p < 0.001] were associated with an increased risk of LRR. A risk model was generated to determine a prognostic index for individual patients with LARC.ConclusionsOverall results after multimodality treatment of LARC are promising. Classification of risk factors for LRR has contributed to propose a prognostic index that could allow us to guide risk-adapted tailored treatment. |
| |
| Keywords: | Locally advanced rectal cancer Intraoperative radiotherapy Surgery External beam radiation therapy |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
