冠心病患者肺炎衣原体感染与C反应蛋白、血脂相互关系的研究

目的探讨冠心病（CHD）患者肺炎衣原体（Cpn）感染与C反应蛋白（CRP）、血脂的相互关系，探讨其可能的发病机制。方法采用微量免疫荧光法检测急性心肌梗死（AMI）组、心绞痛（AP）组度对照蛆患者各35例外周血Cpn IgG抗体，同时测定血脂度CRP。结果AMI组、AP组及对照组血清Cpn IgG抗体阳性率分别为82．2％、65．7％及25．7％，AMI蛆、AP组分别与对照组比较差异有统计学意义（均P〈0．01），但AMI组与AP组间比较差异无统计学意义；血清CRP及血脂总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、我脂蛋白A（apoA）AMI组、AP组显著高于对照组（均P〈0．01），而高密度脂蛋白胆固醇（HDL-C）AMI组、AP组显著低于对照组（P〈0．01），AMI组也明显低于AP组（P〈0．01）；Cpn感染者特异性抗体IgG滴度与血中CRP、TG、LDL-C及apoA有明显相关性（r分别为0．44、0．64、0．36和0．32），而与HDL-C成负相关（r=0．78）（均P〈0．01）。结论CHD患者Cpn感染率明显增高，Cpn可能通过炎症反应及影响脂质代谢在CHD的发生、发展中起作用。

Relation between Chlamydia pneumoniae infection and serum levels of blood fat and C-reactive protein in patients with coronary heart disease

Objective To investigate the relation between Chlamydia pneumoniae(Cpn) infection and serum levels of blood-fat and C-reactive protein(CRP) in coronary heart disease(CHD).Methods The serum specific antibodies to Cpn IgG were measured by using microimmunofluorescence technique in 35 healthy subjects(control group) and CHD patients,including 35 cases of acute myocardial infarction(AMI group),35 cases of angina pectoris(AP group).The levels of blood-fat and CRP were examined.Results The positive rate of Cpn specific IgG antibody was(82.2%) in AMI group,(65.7%) in AP group and(25.7%) in control group,the patients with AMI,AP had significantly higher positive rate of Cpn IgG than the subjects in control group(P<(0.01)).CRP,total cholesterol,triglycerides(TG),low density lipoprotein cholesterol(LDL-C),apolipoprotein A(apoA),apdipoprotein B(apo B) in CHD patients were higher than those in control group(all P<(0.01)),while high density lipoprotein cholesterol(HDL-C) in CHD patients was significantly lower than that in control group(P<(0.01)),HDL-C in AMI group was lower than that in AP group(P<(0.01)).Cpn IgG is related positively to CRP,TG,LDL-C and apoA,but negatively to HDL-C in CHD patients(r=(-0.78))(all P<(0.01)).Conclusion Cpn infection rate significantly increases in CHD patients,Cpn infection may play a role in the pathogenesis of CHD through inflammation and lipid metabolic disturbance.