Corneal endothelial proliferation in anterior synechiae: experimental and clinico-histopathological studies

Corneal endothelial proliferation over the iris was studied on experimental anterior synechiae in rabbits up to 6 months. Clinico-pathologic studies of 102 post-keratoplasty eyes revealed that only 4 out of 51 anterior synechiae were endothelialized. In contrast all 10 leukomatous+ adhesions found in a series of 132 eyes removed after perforating corneal trauma were endothelialized. The above studies suggest that the most important factor for endothelial proliferation is the availability of suitable substrate. The rate of growth depends on growth factors present in anterior chamber.