| L—NNA对兔大脑中动脉阻断后脑梗塞灶范围的影响 |
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| 引用本文： | 田恒力,张天锡,赵卫国,孙青芳. L—NNA对兔大脑中动脉阻断后脑梗塞灶范围的影响[J]. 中风与神经疾病杂志, 1995, 0(1) |
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| 作者姓名： | 田恒力 张天锡 赵卫国 孙青芳 |
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| 作者单位： | 上海第二医科大学附属瑞金医院神经外科 200025(田恒力，张天锡，赵卫国)，上海第二医科大学附属瑞金医院神经外科 200025(孙青芳) |
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| 摘 要： | 电凝阻断兔大脑中动脉,造成兔局灶脑缺血。于缺血前后静脉注射一氧化氮合成酶抑制剂L—NNA,24h后测量梗塞灶范围并与单纯缺血组比较,发现L—NNA扩大兔大脑中动脉阻断后脑梗塞灶范围。另设一氧化氮合成底物L-精氨酸组等进行对照研究。结果证明该作用是由于减少了一氧化氮的生成而产生。
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| 关 键 词： | 脑缺血 脑梗塞 一氧化氮 L-NNA |
L-NNA effecting on volume of cerebral Infarction on rabbit by MCAO |
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| Tian Hengli,Zhang Tianxi,Zhao Weigo,et al.. L-NNA effecting on volume of cerebral Infarction on rabbit by MCAO[J]. Journal of Apoplexy and Nervous Diseases, 1995, 0(1) |
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| Authors: | Tian Hengli Zhang Tianxi Zhao Weigo et al. |
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| Abstract: | We investigated whether N-nitre-L-arginine(L-NNA),acompetitive inhibitor of nitric oxide synthase(NOS), would modify the volume of the focal ischemic infarction produced by middle cerebral artery occlusion(MCAO) in the rabbit,L-NNA(5mg/Kg) or an equivalent volume of saline was infused into New Zealand white rabbits before and after MCAO. After 24 hours ischemia,the infarction volume in L-NN A -treated animals were increased compared with one of controls (19. 28 2. 26mm2VS 15. 62 2. 56mm2,P<0. 05; mean SD). This effect was antagonized by infusion of L-hut not D - argmine. The findings support the view that L-NNA enhances infarction volume by nitric oxide - dependent mechanisms. |
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| Keywords: | Cerebral ischemia cerebtal infarction NO Rabbit |
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