曲美他嗪对急性心肌梗死后无症状左心衰竭患者左室射血分数的影响

目的:观察曲美他嗪对急性非ST段抬高的心肌梗死(NSTEMI)后无症状性左心衰竭患者左室射血分数(LVEF)的影响。方法:45例符合条件的病例被分为常规治疗组(对照组,n=15)及合用曲美他嗪治疗组(曲美他嗪组,n=30)。分别于治疗前及治疗后8wb检测LVEF及心肌缺血总负荷(TIB)。结果:治疗前2组各参数无显著差异,对照组LVEF治疗前后分别为(42.6±5.3)％和(45.5±6.8)％,P<0.01;TIB分别为(5.77±3.32)mm·S和(4.33±2.79)mm·s,P<0.05。曲美他嗪组LVEF治疗前后分别为(41.6±5.2)％和(49.2±1.9)％,P<0.01;TIB分别为(6.25±2.88)mm·s和(2.27±1.46)mm·s,P<0.05。同期2组比较,治疗后曲美他嗪组LVEF显著高于对照组(P<0.01);TIB显著低于对照组(P<0.01)。结论:曲美他嗪可显著改善心肌梗死后无症状性左心衰竭患者的左心功能,可能会改善其长期预后。

Effect of trimetazidine on left ventricular ejection fraction in patients with asymptomatic heart failure after acute myocardial infarction

AIM: To investigate the effect of trimetazidine on left ventricular ejection fraction (LVEF) in patients with asymptomatic heart failure after acute non-ST-segment elevation myocardial infarction (NSTEMI). METHODS: Forty-five patients were enrolled and divided into 2 groups: the control group ( n=15) and the trirnetaziditse group ( u= 30) . All patients accepted routine treatment, and the patients in the trimetazidine group were further treated by trimetai'.i-dine. The indexes of LVEF and total ischemic burden (TIB) were measured in all patients at before treatment and 8 wk after treatment, respectively. RESULTS: The LVEF for the control group were (42.6 + 5.3)% befor treatment and (45.5 + 6.8)% after treatment, respectively ( P < 0.01). The TIB decreased from (5.77 + 3.32) mm-s to (4.33 + 2.79) mnrs (P<0.05). The LVEF for the trimetazidine group were (41.6+5.2)% before treatment and (49.2+ 1.9)% after treatment, respectively (P <0.01). TIB decreased from (6.25 + 2.88) mm-s to (2.27 + 1.46) mm s (P < 0.05). Comparison between 2 groups showed that LVEF in trimetazidine group after treatment remarkably higher than that in control group (P < 0.01), and the TIB was decreased significandy ( P < 0.01) , the rest had no statistic meaning. CONCLUSION: Trimetazidine can improve the LVEF in patients with asymptomatic heart failure after NSTE-MI remarkably. It implicates that trimetazidine may improve the long-term prognosis of the patients.