肝病患者TBA、PA、Cys C、GLDH、CHE检测分析

目的探讨血清前白蛋白（PA）、总胆汁酸（TBA）、谷氨酸脱氢酶（GLDH）、半胱氨酸蛋白酶抑制剂C（CysC）和胆碱酯酶（CHE）联合检测在肝病患者中的变化和临床意义,为其诊断和治疗提供依据。方法 253例肝病患者分为急性肝炎（84例）、慢性肝炎（93例）、肝硬化（46例）、肝癌（30例）4组;56例健康体检者作为对照组,分别检测血清TBA、PA、CHE、GLDH、CysC浓度并进行对照分析。结果肝病患者各组患者PA、CHE浓度明显降低,以肝硬化和肝癌组最为明显;CysC、GLDH、TBA显著升高,依次为肝硬化组、慢性肝炎组、急性肝炎组,与对照组相比,差异均有统计学意义（P〈0.05）。结论 PA、CHE变化反映各型肝炎早期肝细胞的损害程度。TBA、CysC、GLDH是各种肝病的敏感指标,对肝炎的早期诊断及预后判断有重要临床意义。

Detecion and significance of TBA, PA, Cys C, GLDH, CHE of patients with liver diseases

Objective To investigate the change and clinical significance of combined detection of bile acid (TBA), prealbumin (PA), total glutamate homocysteine proteaseInhibitors C (Cys C), dehydrogenase (GLDH) and cholinesterase (CHE) in patients with liver disease and to provide the basis for the diagnosis and treatment. Methods Total of 253 patients with liver disease were divided into 4 groups: patients with acute hepatitis (84 cases), chronic hepatitis (93 cases), liver cirrhosis (46 cases) and liver cancer (30 cases); 56 cases of healthy persons were taken as the control group. Serum concentration of TBA, PA, Cys C, GDLH and CHE were detected and analyzed, respectively. Results The concentration of PA and CHE reduced significantly in all patients with liver disease, which were more obvious in patients with liver cirrhosis and liver cancer; TBA, Cys C and GLDH were significantly increased, following by liver cirrhosis group, chronic hepatitis group and acute hepatitis group, which were statistically significant compared with the control group (P < 0.05). Conclusions Variation on concentration of PA and CHE can reflect the damage degree of liver cells in early stage of hepatitis. TBA, Cys C and GLDH are sensitive indexes of all sorts of liver disease, which has important clinical significance for early diagnosis and prognosis of hepatitis.