磁共振扩散加权成像在软组织肿瘤诊断中的应用

目的 探讨磁共振扩散加权成像( DWI)在软组织肿瘤诊断中的应用价值.方法 对经手术病理证实的48例软组织肿瘤患者行MRI扩散加权成像,其中软组织恶性肿瘤28例,良性肿瘤20例.选择感兴趣区进行表观扩散系数( ADC)值的测定,并进行统计学分析.结果 软组织恶性肿瘤感兴趣区的ADC值(0.95±0.31)×10-3mm2/s明显低于软组织良性肿瘤的ADC值(1.87±0.66)×10-3mm2/s和肌肉组织( 1.62±0.50)×10-3mm2/s的ADC值(t=2.975、2.067,P＜0.05),软组织良性肿瘤与肌肉组织的ADC值差异无统计学意义(P＞0.05).ADC值为s1.35×10-3mm2/s时,鉴别良恶性肿瘤的敏感性为75％,特异性为89％.结论 软组织肿瘤ADC值测定在良恶性鉴别诊断中有重要价值.

Application of diffusion-weighted imaging for the differential diagnosis of soft-tissue tumors

Objective To explore the potential value of diffusion weighted imaging（DWI） in the clinical diagnosis of soft-tissue tumors. Methods Diffusion-weighted MRI was performed in 48 histologically proven soft-tissue tumor cases using diffusion-weighted spin-echo sequences. Of the 48 soft-tissue tumor cases, there were 28 cases of sarcoma and 20 cases of benign tumor. The apparent diffusion coefficient（ADC） values of a large region with no necrosis, scar tissue, hemorrhage or calcification representing the lesion were measured. ADC values of benign tumors, malignant tumors and normal muscles were compared. Results The ADC value of the malignant tumors （0.95 ± 0.31 ） ×10^-3mm2/s was significantly lower than that of benign lesions（ 1.87±0.66）×10^-3mm2mm//s and muscles（ 1.62 ± 0. 50 ）×10^-3mm2/s. There was no significant difference in ADC value between benign lesions and muscles. Sensitivity（75% ） and specificity（89% ） were obtained when the ADC value was 1.38 ×10^-3mm2/s in the differentiation of benign and malignant tumors. Conclusion Diffusion-weighted MRI had potential value in differentiating benign softtissue tumors from malignant ones.