原发性干燥综合征患者B细胞活化因子受体的表达

目的 检测原发性干燥综合征(pSS)患者血清中B细胞活化因子受体(BAFF-R)的表达,探讨其在pSS发病中的作用.方法 pSS患者120例,采用酶联免疫吸附法(ELISA)检测血清BAFF-R水平,对照组62例为健康体检者,性别、年龄构成与患者组匹配.分析血清BAFF-R表达与免疫指标、炎性指标及自身抗体的相关性.结果 血清BAFF-R平均水平pSS组为(692.7±536.9)ng/L,对照组为(279.7±186.9)ng/L,pSS组明显高于对照组(P＜0.01).血清BAFF-R水平与免疫球蛋白IgG呈正相关(r=0.429,P＜0.01),与免疫球蛋白IgA、IgM、补体C3、C4、类风湿因子、红细胞沉降率、C反应蛋白无明显相关性.抗核抗体、抗SSA抗体、抗SSB抗体阳性者血清BAFF-R水平高于阴性者.随着抗核抗体滴度的增加,血清BAFF-R水平呈平行增高趋势.结论 pSS患者中BAFF-R表达增高,并与免疫球蛋白定量、自身抗体表达呈相关性.BAFF-R的异常表达参与了pSS的发病.

Expression of B cell activating factor-receptor in the sera of patients with primary Sj(o)gren' s syndrome

Objective To determine the serum levels of B cell activating factor-receptor（BAFF-R） in pa- tients with primary Sjogren＇ s syndrome （ pSS ） and investigate the role of BAFF-R in the pathogenesis of pSS. Methods The serum concentration of BAFF-R was measured by ELISA in 120 patients with pSS and 62 age-and sex-matched normal controls. Results The median level of serum BAFF-R was （ 692.7 ± 536.9 ） ng/L in pSS and （279.7 ±186. 9 ）ng/L in healthy controls. The serum level of BAFF-R in the pSS was significantly higher than normal controls（ P 〈 0.01 ）. Higher level of BAFF-R was associated with higher level of IgG（ r = 0. 429, P 〈 0.01 ）. Serum level of BAFF-R had no correlation with IgA, IgM, C3, C4, RF, ESR and CRP. BAFF-R level was markedly increased in patients with positive ANA, anti-SSA, anti-SSB antibody compared with those with negative antibody. Conclusion The serum BAFF-R level was significantly elevated and correlated with the level of immunoglobulin and autoantibodies. BAFF-R play certain role in the pathogenesis of pSS.