联合检测卵巢癌患者血清CA125、CA72-4和肿瘤特异性生长因子的价值

目的 探讨联合检测血清CA125、CA72-4和肿瘤特异性生长因子(TSGF)对卵巢癌临床诊断、疗效观察及病情监测的价值.方法 采用化学发光免疫测定法检测68例卵巢癌患者,53例卵巢良胜肿瘤患者及50例健康妇女的血清样本中CA125和CA72-4含量,采用化学比色法定量检测TSGF含量.检测数据结合临床资料进行统计学分析.结果 卵巢癌组血清CA125、CA72-4和TSGF含量明显高于卵巢良性肿瘤组和健康妇女组(均P＜0.01).三项肿瘤标志物联检的敏感度为91.2％,特异度为83.0％,准确度为87.4％,敏感度和准确度均高于任一单项检测,特异度与单项检测CA125时保持一致.手术治疗后5d,卵巢癌患者血清CA125、CA72-4、TSGF含量明显低于术前水平(均P＜0.05).结论 血清CA125、CA72-4与TSGF联检可以提高卵巢癌早期诊断的检出率,对卵巢肿瘤的良恶性辅助诊断及鉴别诊断具有一定应用价值,对卵巢癌的术后监测和疗效观察也具有重要价值.

Clinical Value of serum CA125 ,CA72-4 and TSGF in ovarian cancer

Objective To investigate the clinical value of combined detection of the serum levels of CA125, CA72-4 and tumor specific growth factor（TSGF） in the diagnosis of ovary cancer and the curative effect. Methods Serum levels of CA125 ,CA72-4 and TSGF in 68 patients with ovary cancer,53 patients with benign ovary tumor and 50 normal controls were measured by chemiluminescent immunoassay（CLIA） and chemical colorimetry. Results and clinical data were statisticaly analyzed. Results The levels of CA125, CA72-4 and TSGF in ovary cancer group were higher than that in the benign ovarian tumor group and healthy controls（ all P 〈0. 01 ）. When use three tumor markers united detection, sensitivity, specificity and accuracy were 91.2% ,83.0% and 87.4% respectively. The sensitivity and accuracy was higher than any single detection. The specificity with single CA125 testing was consistently. The levels of CA125, CA72-4 and TSGF in patients with ovary cancer were significandy different after surgical treatment for five days（ all P 〈0.05）. Conclusion The combined detection of the three markers may increase the positive rate in the early diagnosis of ovarian cancer, and help to differentiate the benign and malignant ovarian tumor, but also is valuable to observe the curative rate and postoperative monitor of the ovary cancer.