急性腔隙性脑梗死患者血糖、血脂、尿酸及纤维蛋白原水平与预后的关系

目的 探讨急性腔隙性脑梗死患者血糖、血脂、血尿酸及纤维蛋白原水平与预后的关系.方法 回顾性分析127例急性腔隙性脑梗死患者的临床资料,并把血糖、血脂、尿酸及纤维蛋白原水平正常者64例分为A组,异常者63例分为B组,平均随访2年,观察两组神经功能缺损程度、再梗死发生率及血管性痴呆发生率.结果 经治疗4周后,A组神经功能缺损评分(9.6±7.3)分,明显低于B组的(14.3±7.4)分(t =3.8696,P＜0.05)；A组总有效率95.4％明显高于B组的82.0％(x2=5.8623,P＜0.05).平均随访2年后,A组脑梗死再发率18.8％ (12/64)、血管性痴呆率7.8％ (5/64),均明显低于B组的28.6％( 18/63)、17.5％ (11/63)(x2=6.5421、5.9623,均P＜0.05).结论 多项血清生化指标异常对急性腔隙性脑梗死近、远期预后均有重要影响.

Relationship of blood glucose, blood lipids, blood uric acid and fibrinogen level, and prognosis of acute lacunar cerebral infarction patients

Objective To investigate the relationship of blood glucose,blood lipids,serum uric acid,fibrinogen level and prognosis of patients with acute lacunar cerebral infarction. Methods Clirical data of 127 cases with a- cute lacunar cerebral infarction were retrospectively analyed. Patients with normal blood glucose, blood lipid, uric acid and fibrinogen level were enrolled into A group of 64 cases ,63 cases with abnormal levels were selected as group B, an average of 2 years of follow-up, observing the two groups of neurologie, re-infarction incidence and prevalence of vascular dementia were obsenved in two groups. Results After 4 weeks of treatment,A group of neural function defect score （9.6 ± 7.3 ） was significantly lower than group B （ 14.3 ± 7.4 ） （ t = 3. 8696,P 〈 0. 05 ） ;95.4% total effective rate in A group was significantly higher than B group of 82.0% （ X2 = 5. 8623, P 〈 0. 05 ）. After an average follow-up of 2 years, A group of recurrent cerebral infarction rate（ 18.8% ） ,vascular dementia rates（7.8% ） ,were significantly lower than group B （ 28.6% ）, 17.5 % （ 11/63 ） （ X2= 6. 5421,5. 9623, P 〈 0. 05 ）. Conclusion A number of abnormal serum biochemical indexes had a significant impact on short and long-term prognosis of acute lacunar cerebral infarction.