两种方法治疗支气管哮喘伴过敏性鼻炎疗效比较

目的 比较采用丙酸氟替卡松气雾剂联合鼻喷剂与单纯丙酸氟替卡松气雾剂治疗支气管哮喘伴过敏性鼻炎的疗效.方法 50例支气管哮喘伴过敏性鼻炎患者随机分成观察组和对照组各25例,观察组吸入丙酸氟替卡松气雾剂加丙酸氟替卡松鼻喷剂,对照组吸入丙酸氟替卡松吸入气雾剂.随访6个月,分别于1、3、6个月检测两组治疗后肺功能:1s用力呼气量占正常预计值的百分比(FEV1％)、哮喘急性发作次数、无症状天数.结果 观察组治疗后1、3、6个月FEV1％分别为(107.2±15.3)％、(115.3±11.9)％、(131.3±10.9)％,均明显高于对照组的(98.6±13.6)％、(102.6±13.6)％、(126.5±9.7)％(t=2.306、3.355、3.714,均P＜0.05).观察组治疗期间发生支气管哮喘次数(0.13±0.11)次、无症状天数(150.2±14.3)d、鼻炎发作次数(0.25±0.31)次,对照组分别为(0.30±0.44)次、(116.5±23.1)d、(0.65±0.24)次,两组差异均有统计学意义(t =2.413、3.435、3.734,均P＜0.05).结论 丙酸氟替卡松气雾剂联合鼻喷剂治疗支气管哮喘伴过敏性鼻炎疗效显著,值得临床推广应用.

Therapeutic effect of two threapies for bronchial asthma complicated with allergic rhinitis

Objective To compare therapeutic effects of fluticasone propionate aerosol combined with fluticasone nasal pray and alone fluticasone propionate aerosol for bronchial asthma complcated with allergic rhinitis. Methods Fifty asthmatic children with allergic rhinitis were randomly divided into observation group and control group. Observation group were treated with flnticasone propionate aerosol combined with flutieasone nasal pray, control group were treated with flutieasone propionate aerosol alone. All the patients were observed for 6 months. The lung function parameters （FEV1% ）, the number of acute asthma symptom, the number of days without acute asthma symptom, the number of acute allergic symptoms at one month, three months, six months after the treatment, were observed. Results FEV1%ofobservation group were（107.2±15.3）%,（115.3 ±11.9）%,（131.3 ±10.9）%,and were significantly improved（98.6±13.6） %, （ 102.6 ± 13.6） %, （ 126.5 ±9.7 ） %, （ t = 2. 306,3. 355,3. 714, all P 〈 0. 05 ） at one month, three months, six months after the treatment. The number of acute asthma symptom, the number of days without acute asthma symptom, the number of acute allergic symptoms of observation group were （0. 13± 0. 11） ,（150.2 ±14.3） ,（0.25 ±0.31） ,and control group were（0.30 ±0.44） ,（116.5 ±23.1）, （0.65 ±0.24）, Observation group had significant difference compared with control group （ t = 2. 413,3. 435,3. 734, all P 〈 0.05 ）. Conclusion There was significant therapeutic effect of fluticasone propionate aerosol combined with fluticasone nasal pray for bronchial asthma complicated with allergic rhinitis, and was worthy of clinical application