| Serum level of MMP-2, MMP-9 and Ox-LDL in Alzheimer＇s disease with hyperlipoidemia |
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| 引用本文： | 蔡志友,晏勇,晏宁,王凤英,黄华,王咏龙,赵宇.Serum level of MMP-2, MMP-9 and Ox-LDL in Alzheimer＇s disease with hyperlipoidemia[J].中国人民解放军军医大学学报,2007,22(6):352-356. |
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| 作者姓名： | 蔡志友 晏勇 晏宁 王凤英 黄华 王咏龙 赵宇 |
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| 作者单位： | [1]Department of Neurology, First Affiliated Hospital, Chongqing Medical University, Chongqing 400016,China [2]Department of Neurology, First Affiliated Hospital, Zunyi Medical College, Guizhou 563003, China |
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| 摘 要： | Objective：To investigate serum levels of MMP-2,MMP-9, oxidized low-density lipoprotein （ox-LDL） in Alzheimer＇s disease （AD） patients and study the possible pathway and mechanism of AD with abnormal lipid metabolism. Methods： Subjects in this study were divided into 4 groups ： normal lipid group without AD （N）, hyperlipoidemia group without AD （H）, normal group with AD （A）, hyper- lipoidemia group with AD （AH）. There were 15 individuals in each group. MMP-2, MMP-9, ox-LDL was measured by enzyme linked immunosorbent assay （EL1SA）. Serum lipids levels were measured by biochemical methods. Results： The serum levels of MMP-2, MMP-9, ox-LDL were significantly higher in H, A and AH groups than those in N group. Those of ox-LDL in H, AH groups was higher than that of in A group. The serum level of MMP-2, MMP-9 in AH groups were higher than that of in H group. The score of mini-mental state examination （MMSE） in A and AD groups was negatively correlated with the serum level of ox-LDL. Relationship between the score of MMSE and the serum level of ox-LDL in AD groups and non-AD groups had statistical significance. Conclusion： MMP-2, MMP-9, ox-LDL and abnor- mal lipid metabolism may participate in pathogenesis of AD, in which abnormal lipid metabolism induces expressions of MMP-2,MMP-9 and ox-LDL. Oxidative stress and blood-brain barrier disruption might ac- celerate the process of AD.
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| 关 键 词： | 阿耳茨海默氏病 早老性痴呆 高脂血 血清检测 |
| 收稿时间： | 2007-06-11 |
| 修稿时间： | 2007-11-29 |
Serum level of MMP-2, MMP-9 and Ox-LDL in Alzheimer's disease with hyperlipoidemia |
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| CAI Zhi-you,YAN Yong,YAN Ling,WANG Feng-ying,HUANG Hua,WANG Yong-long,ZHAO Yu.Serum level of MMP-2, MMP-9 and Ox-LDL in Alzheimer''''s disease with hyperlipoidemia[J].Journal of Medical Colleges of PLA(China),2007,22(6):352-356. |
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| Authors: | CAI Zhi-you YAN Yong YAN Ling WANG Feng-ying HUANG Hua WANG Yong-long ZHAO Yu |
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| Institution: | 2. Department of Neurology, Universitair Ziekenhuis Brussel, Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Belgium;3. Department of Vascular Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands;2. Department of Clinical Biochemistry, Hospital of South West Jutland, Esbjerg, Denmark;1. Department of Neurology, Third Affiliated Hospital of Sun Yat-sen University, China;2. School of Mathmatics and Computational Science, Sun Yat-sen University, China;3. Department of Neurology, Second Affiliated Hospital of GuangZhou Medical University, China;4. Department of clinical laboratory, Third Affiliated Hospital of Sun Yat-sen University, China;5. Department of Neurology, Fifth Affiliated Hospital of Sun Yat-sen University, China;1. Department of Neurology, Shanghai Ninth People''s Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shangaï, China;2. Pôle Information Médicale Evaluation Recherche Hospices Civils de Lyon, Lyon, France and Université Lyon 1 et Equipe d''Accueil 4129 Lyon, France;3. Cerebrovascular Unit, Department of Neurology, Université Claude Bernard, Lyon, France;4. Laboratoire d''hématologie, CBPE, Hospices Civils de Lyon, Lyon, France |
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| Abstract: | ObjectiveTo investigate serum levels of MMP-2,MMP-9, oxidized low density lipoprotein (ox-LDL) in Alzheimer's disease (AD) patients and study the possible pathway and mechanism of AD with abnormal lipid metabolism. Methods Subjects in this study were divided into 4 groups normal lipid group without AD (N), hyperlipoidemia group without AD (H), normal group with AD (A), hyperlipoidemia group with AD (AH). There were 15 individuals in each group. MMP-2, MMP-9, ox-LDL was measured by enzyme linked immunosorbent assay (ELISA). Serum lipids levels were measured by biochemical methods. Results The serum levels of MMP-2, MMP-9, ox-LDL were significantly higher in H, A and AH groups than those in N group. Those of ox LDL in H, AH groups was higher than that of in A group. The serum level of MMP-2, MMP-9 in AH groups were higher than that of in H group. The score of mini-mental state examination (MMSE) in A and AD groups was negatively correlated with the serum level of ox-LDL. Relationship between the score of MMSE and the serum level of ox-LDL in AD groups and non-AD groups had statistical significance. Conclusion MMP-2, MMP-9, ox-LDL and abnormal lipid metabolism may participate in pathogenesis of AD, in which abnormal lipid metabolism induces expressions of MMP-2,MMP-9 and ox-LDL. Oxidative stress and blood-brain barrier disruption might accelerate the process of AD. |
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| Keywords: | Alzheimer's disease matrix metalloproteinase blood-brain barrier lipid metabolism |
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