In vitro chemosensitivity testing in the treatment of ovarian carcinoma |
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Authors: | H. Auner E. Petru H. M. H. Hofmann H. Pickel P. Pürstner |
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Affiliation: | (1) Department of Obstretrics and Gynecology, University of Graz, Austria;(2) Universitäts-Frauenklinik, Auenbrugger Platz 14, A-8036 Graz |
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Abstract: | Summary In vitro chemosensitivity to cisplatinum, adriamycin, cyclophosphamide, and 5-fluorouracil was investigated in 58 cases of ovarian carcinoma using Volm's short-term test. These in vitro results were retrospectively correlated with the relapse-free interval. Operative treatment in all patients (FIGO stage I (5), III (43), IV (10)) comprised maximum debulking procedure including hysterectomy, adnexectomy, omentectomy, pelvic and in most cases additionally paraaortic lymphadenectomy. Subsequently, all patients were treated with the cisplatinum-epirubicin-cyclophosphamide regimen. 33/58 tumors (66%) were sensitive in vitro (inhibition of nucleic acid precursor incorporation of more than 45% as compared to untreated controls). The median relapse-free interval of patients with sensitive tumors was significantly longer than that of those with resistant carcinomas (30.3 versus 22.6 months, respectively;P<0.05). Histopathological evaluation showed the majority of serous cystadenocarcinomas to be sensitive (26/33=79%,P<0.05). |
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Keywords: | Chemosensitivity, short-term assay Ovarian carcinomas Relapse-free interval |
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