肿瘤抑制因子TIMP2在肺癌组织中的表达及其临床意义

[目的]探讨肿瘤抑制因子TIMP2在肺癌组织中的表达及其与各临床指标关系。[方法]采用免疫组织化学染色方法检测94例肺癌患者肿瘤组织和相应的正常肺组织中TIMP2蛋白的表达水平。[结果]TIMP2蛋白的免疫组化染色显示主要为细胞浆着色。TIMP2肺泡阳性表达率为64．20％，支气管阳性表达率63．51％，肿瘤组织阳性表达率为30．85％。经统计学分析结果显示TIMP2蛋白肿瘤组织内表达水平与周围正常肺泡和支气管表达有明显差异（P〈0．001）。[结论]肺癌组织中TIMP2蛋白水平显著降低，提示其在肺癌的发生过程中蛋白表达受到显著抑制。

Expression of TIMP2 in Lung Cancer Tissues and Its Significance

[Purpose] To investigate the expression of TIMP2 in lung cancer tissues and its rela- tionship with clinical characteristics. [Methods] The TIMP2 protein levels in ninety-four tumor tissues and corresponding normal tissues,including squamous cell carcinoma （SCC） 42 cases, lung adenocarcinoma（ADC） 43 cases,small cell lung cancer（SCLC） 7 cases and others 2 cases, were examined by immunohistochemical （IHC）. [Results] IHC results showed that positively stained of TIMP2 was 30.85% in tumor tissues,which was significantly lower than that in normal alveoli tissues （64.20%, P〈0.001） and normal bronchial （63.51%, P〈0.001 ）. [Conclusion] The expression level of TIMP2 protein decreases in lung cancer tissues,which indicates that its ex- pression may be significantly suppressed in lung cancer carcinogenesis.