D-二聚体、hs-CRP及MMP-9水平联合监控在急性缺血性脑梗死患者中的临床意义

目的 探讨D-二聚体水平、hs-CRP及MMP-9联合监控在急性缺血性脑梗死患者中的临床意义.方法 选取2014年3月至2016年3月收治的急性缺血性脑梗死患者80例,同期选取健康体检者80例,分别测定2组D-二聚体、hs-CRP及MMP-9水平,及不同程度(轻度、中度、重度)急性缺血性脑梗死患者的D-二聚体、hs-CRP及MMP-9的水平,并分析D-二聚体、hs-CRP及MMP-9在急性缺血性脑梗死患者的相关性.结果 急性脑缺血性脑梗死组D-二聚体、hs-CRP及MMP-9水平(1.49±0.12) mg/L、(11.38±2.12) mg/L、(332.27±54.62) μg/L]高于健康组(0.25±0.04) mg/L、(2.14±0.51)mg/L、(124.68±27.59) μg/L],差异有统计学意义(P＜0.05);轻度急性脑缺血性脑梗死组D-二聚体、hs-CRP及MMP-9水平(0.68±0.14) mg/L、(3.16±0.87) mg/L、(227.48±43.26) μg/L]低于中度组(1.13±0.25) mg/L、(7.54±1.3)mg/L、(325.69±62.74)μg/L]、且低于重度组(1.54 ±0.37) mg/L、(13.49±1.50) mg/L、(497.23±74.35) μg/L],差异有统计学意义(P＜0.05);急性脑缺血性脑梗死患者D-二聚体、hs-CRP及MMP-9水平均呈正相关(P＜0.05).结论 联合监控D-二聚体、hs-CRP、MMP-9水平能够辅助急性脑缺血性脑梗死患者的诊断,并可评估疾病的进展,指导临床治疗.

Clinical significance of combination monitoring of D-dimer,hs-CRP and MMP-9 levels in patients with acute ischemic cerebral infarction

Objective To investigate the clinical significance of combination monitoring of D-dimer,hypersensitive C-reactive protein,(hs-CRP) and matrix metalloproteinases-9 (MMP-9) levels in patients with acute ischemic cerebral infarction.Methods Eighty patients with acute ischemic cerebral infarction who were admitted and treated in our hospital from March 2014 to March 2016 were enrolled as case group,at the same time,the other 80 healthy subjects were served as control group.The serum levels of D-dimer,hs-CRP and MMP-9 were detected in both groups,moreover,the patients in case group were redivided into mild case group,moderate case group and severe case group.Besides the correlation among D-dimer,hs-CRP and MMP-9 in patients with acute ischemic cerebral infarction was analyzed.Results The serum levels of D-dimer,hs-CRP and MMP-9 in case group were (1.49 ± 0.12) mg/L,(11.38 ± 2.12) mg/L,(332.27 ± 54.62) μg/L,respectively,which were significantly higher than those (0.25 ± 0.04) mg/L,(2.14 ± 0.51) mg/L,(124.68 ± 27.59) μg/L],respectively in control group (P ＜ 0.05).Moreover the serum levels of D-dimer,hs-CRP and MMP-9 in mild case group were (68 ± 0.14) mg/L,(3.16 ± 0.87) mg/L,(227.48 ± 43.26) μg/L,respectively,which were significantly lower than those (1.13 ± 0.25) mg/L,(7.54 ± 1.3) mg/L,(325.69 ± 62.74) μg/L],respectively in moderate case group and those (1.54 ±0.37) mg/L,(13.49 ± 1.50) mg/L,(497.23 ± 74.35) μg/L] in severe case group (P ＜ 0.05).Besides there was a positive correlation among the serum levels of D-dimer,hs-CRP and MMP-9 (P ＜ 0.05).Conclusion The combination monitoring of D-dimer,hs-CRP and MMP-9 levels is helpful for the diagnosis of acute ischemic cerebral infarction,moreover,which can evaluate the development of the diseases to guide clinical treatment.