自杀基因联合其他疗法治疗肿瘤的研究进展

肿瘤的基因治疗经多年研究已取得了许多令人瞩目的成就，其中自杀基因疗法的发展尤为迅速，是一种颇具临床应用前景的基因治疗策略。但是自杀基因治疗的单独应用仍有不少局限性，如转染效率低、诱导免疫反应能力弱、缺乏组织特异性、易引起肿瘤耐药性、对肿瘤细胞类型有依赖等。所以，研究自杀基因与其他肿瘤疗法的联合应用以及不同自杀基因之间协同作用以寻求更有效的抗肿瘤效应已逐渐成为非常有前景的治疗手段。本文就近几年自杀基因联合其他疗法治疗肿瘤的研究进展作综述。

Progress on treatment of tumor using suicide gene combined with other therapies

Gene therapy for tumor has made remarkable achievement after years of efforts. Among many strategies of cancer gene therapy, the suicide gene therapy is developing rapidly. It is potentially a clinical application as a gene therapy for tumor. However, there are also many limitations when using suicide therapy alone, such as low transfection efficiency; weak capability in inducing immune response; lack of tissue specificity; easy to cause tumor drug resistance; dependence on tumor cell types. Therefore, suicide gene therapy in combination with other tumor therapies or with other suicide gene therapy has been the promising approaches. This review introduces these strategies and relevant research development.