肌萎缩性侧索硬化症患者神经传导速度的研究

目的：探讨肌萎缩性侧索硬化症（ALS）患者神经传导速度（NCV）的改变及其在诊断和鉴别诊断中的价值。方法：以106例确诊为ALS的患者和123例正常人为研究对象，应用Keypoint肌电图仪进行正中、尺、胫和腓总神经的NCV检查，记录和刺激电极均为表面电极。结果：ALS组正中神经感觉神经传导速度（SCV）和正中、尺、腓总神经运动神经传导速度（MCV）较正常对照组明显降低，除正中神经感觉神经潜伏期外，两组比较，差异均有显著性意义；正中、尺、胫神经复合肌肉动作电位波幅ALS组明显低于正常组，但多无神经传导阻滞。结论：ALS组的MCV和SCV较正常对照组明显减慢，但在诊断和鉴别诊断方面，临床表现及针极肌电图比NCV更有价值。

Study of nerve conduction velocity in patients with amyotrophic lateral sclerosis

Objective: To analysis the finding of never conduction velocity(NCV) in patients with ALS and investigate the clinical significance of NCV. Methods: Keypoint was applied to estimate the NCV of median,ulnar,tibial,peroneal in 106patients with ALS and 123healthy volunteers,in which sunface electrodes was used for both stimulating and recording. Results: SCV of median and MCV of median,ulnar,peroneal in patient group was a significant difference as compared with the normal subjects;A significant difference was noted in all latency except sensory fiber of median.A significant differencence of compound muscle action potential amplitude of medial,ulnar,tibial was noted in two groups. Conclusion: NCV in patients with ALS could show abnormal slowing,so the valuation for differentiation of NCV is not so good as the clinical signs and the distribution of electromyographic abnormalities.