丙戊酸镁与丙戊酸钠及碳酸锂治疗躁狂发作对照研究

目的：比较丙戊酸镁与丙戊酸钠及碳酸锂治疗双向情感障碍的疗效及不良反应。方法：将120例双相情感障碍躁狂发作的患者随机均分为丙戊酸镁组、丙戊酸钠组及碳酸锂组，在治疗前，治疗2、4、6周末分别用Bech-Rafaels—en躁狂量表（BRMS）和临床疗效总评量表（CGI）及副反应量表（T段S）评定疗效和不良反应。结果：三组治疗2、4、6周后BRMS总分，及各因子分比治疗前明显降低，差异显著。治疗2、4、6周末TESS评分，丙戊酸镁组分别显著低于丙戊酸钠及碳酸锂组，差异有显著性，丙戊酸钠组显著低于碳酸锂组，差异有显著性。结论：丙戊酸镁治疗躁狂发作疗效好，起效快，不良反应小。

A Control Study of Magnesium Valproate and Sodium Valproate and Lithium Carbonate in the Treatment of Manic Episode

Objective： To observe the efficacy and side effects of Magnesium Valproate and sodium valproate and lithi- um carbonate in the treatment of manic episode. Methods： One hundred and twenty patients with manic episode were di- vided into study group（Magnesium Valproate） and control group（sodium valproate and lithium carbonate） randomly. Efficacy and side effects were assessed with BRMS,C_~I and TESS respectively before treatment and after treatment for 2,4,6 weeks. Results：After 2,4,6 weeks treatment, the total score of BRMS and the score of each factor were signifi- cantly lower than that before treatment in three groups, andthe scores of treatment factors and TESS was significantly lower in study group than in control group. Conclusion：Magnesium Valproate is more effective and well tolerated in the treatment of manic episode.