Antinociceptive,anti-inflammatory,and antipyretic properties of an aqueous extract of Dicranopteris linearis leaves in experimental animal models |
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Authors: | Zainul Amiruddin Zakaria Zuleen Delina Fasya Abdul Ghani Raden Nur Suraya Raden Mohd. Nor Hanan Kumar Gopalan Mohd. Roslan Sulaiman Abdul Manan Mat Jais Muhammad Nazrul Somchit Arifah Abdul Kader Johari Ripin |
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Affiliation: | (1) Faculty of Pharmacy, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia;(2) Faculty of Biotechnology and Life Sciences, Universiti Industri Selangor, Jalan Zirkon A7/A, Seksyen 7, 40000 Shah Alam, Selangor, Malaysia;(3) Department of Biomedical Sciences, Faculty of Medicine and Health Science, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia;(4) Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia |
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Abstract: | This study was performed out to establish the antinociceptive, anti-inflammatory, and antipyretic properties of an aqueous extract of Dicranopteris linearis leaves in experimental animals. The antinociceptive activity was measured using the abdominal constriction, hot plate, and formalin tests. The anti-inflammatory and antipyretic activities were measured using the carrageenan-induced paw edema and brewer’s yeast-induced pyrexia tests, respectively. The extract, obtained after 72 h soaking of the air-dried leaves in distilled water and then prepared in the doses of 13.2, 66.0, 132.0, and 660.0 mg/kg, was administered subcutaneously 30 min before subjecting the animals to the assays mentioned above. Generally, the extract, at all doses used, was found to have significant (P < 0.05) concentration-independent antinociceptive, anti-inflammatory, and anti-pyretic activity. In conclusion, the aqueous extract of D. linearis has antinociceptive, anti-inflammatory, and antipyretic activity, supporting previous claims of its traditional use by the Malays to treat various ailments, particularly fever. |
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Keywords: | Dicranopteris linearis Antinociceptive Anti-inflammatory Antipyretic Aqueous extract |
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