厚朴提取物中主要成分的小肠吸收特性

目的从其吸收部位、药物浓度两个方面对厚朴的主要成分和厚朴酚、厚朴酚的吸收特性进行研究。方法采用在体大鼠肠段回流实验。结果和厚朴酚、厚朴酚在小肠上部吸收最佳 ;在小肠中部及下部吸收无明显差异 ,但较小肠上部相比稍差。和厚朴酚、厚朴酚在肠道中的吸收量与其浓度成线性关系 ,随着药物浓度的增大吸收量增加 ,其吸收百分率基本不变。结论和厚朴酚、厚朴酚在肠道中吸收良好 ,吸收机制为被动转运

Absorptive feature of honokiol and magnolol in the rat′s intestines

Objective To study the feature of honokiol and magnolol absorption in the intestines.Methods With the ligation test in the segment of the intestines of a rat in vivo, the effect of the segments of intestines and drug concentrations of absorption of honokiol and magnolol has been studied. Results The absorption of honokiol and magnolol was best in the duodenum.The absorption of honokiol and magnolol in the midgut was as well as that in lieum.The absorption was liner at diffrernt concentrations and the absorption fraction was kept unvaried at different concentrations.No saturation phenomenon occurred.Conclusions The mechanism of the gastrointestinal absorption of honokiol and magnolol is passive diffusion.