人脑胶质瘤中CD15、Ki-67的表达及其临床意义

目的研究细胞粘附分子CD15及Ki-67抗原在人脑胶质瘤中的表达及其临床意义。方法应用免疫组化S-P法检测例正常脑组织和858例人脑胶质瘤组织中CD15和Ki-67的表达。结果CD15和Ki-67在正常脑组织中均不表达,而在各级别的人脑胶质瘤中均有表达差异极显著,(P<0.01)。CD15和Ki-67的表达在高级别胶质瘤中均显著高于低级别胶质瘤(P<0.01),且CD15和Ki-67的表达呈显著正相关(P<0.05,r=0.462)。结论Ki-67可以作为评估胶质瘤细胞增殖的良好指标,CD15和Ki-67的表达可为判断胶质瘤的恶性程度和临床病理分级提供有意义的依据。

Expressions of CD15 and Ki-67 in Human Glioma and Their Clinical Significance

Objective To study CD15 and Ki-67 antigens expressions in human glioma and their significance. Methods The expressions of CD15 and Ki-67 were detected in 58 cases of human glioma and 8 specimens of normal brain tissue by immunohi-stochemical staining(S-P methods). Their clinical significance and the correlation between the CD15 and Ki-67 were analyzed. Results The CD15 and Ki-67 were not expressed in all the normal brain tissue, but the expressions of CD15 and Ki-67 could be detected in all the grades of gliomas. There was significant difference in the expressions of CD15 and Ki-67 among the normal brain tissue group, the low grade gliomas group and the high grade gliomas group (P<0.01). There was a significantly positive correlation (P<0.05) between the expressions of CD15 and Ki-67 and histological grade of human glioma. Conclusions The expressions of CD15 and Ki-67 are helpful to judging malignant degree of human glioma and its pathological grade. The expression level of Ki-67 may be a useful index of proliferation of the glioma cell.