Analysis of clinical course of postoperative recurrence in Crohn's Disease of distal ileum

In the present study we have investigated whether in patients with Crohn's Disease the clinical course remains the same from the initial disease to postoperative recurrent disease. Fifty-eight resected patients who developed a postoperative recurrence were followed for 4.2±3 years (median 3 years). The yearly frequency of flare-up was 1.9±1.0 (median 1.5) in the initial disease and 1.7±1.0 (median 1.7) in recurrent disease. In patients who experienced complications during the initial disease, the frequency of complications during the course of recurrent disease was significantly higher than in the others (27/42 vs 3/16,P=0.002). The frequency of obstruction and extraintestinal manifestations in the recurrent disease was higher in patients who suffered these complications in the initial disease than in those who did not (19/29 vs 6/29,P=0.0006, and 4/5 vs 4/53,P=0.0008). The cumulative probability of complication during the course of recurrent disease was higher in patients with complications during the initial disease (P<0.001). The survival analysis showed that the cumulative probability of obstruction and extraintestinal complication in recurrent disease was higher in patients who suffered these complications in the initial disease (P<0.005). These data indicate that the clinical course of Crohn's disease of the distal ileum remains the same from the initial disease to postoperative recurrent disease. This study also suggests that the short-term course of recurrent disease can reasonably be predicted.This work was supported in part by a grant from the University of Rome La Sapienza (85/280/02.12.01.28).