| 不同癌基因在口腔白斑和鳞癌中表达的研究 |
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| 引用本文： | 陈黎明,田茂能,蒋开鸣,李燕. 不同癌基因在口腔白斑和鳞癌中表达的研究[J]. 临床口腔医学杂志, 2002, 18(1): 49-51 |
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| 作者姓名： | 陈黎明 田茂能 蒋开鸣 李燕 |
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| 作者单位： | 550002,贵州,贵阳,市口腔医院 |
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| 摘 要： | 目的 研究正常口腔黏膜，口腔黏膜白斑及口腔鳞癌组织中不同癌基因的表达。方法 通过HE染色确定口腔黏膜组织类型，提取组织中RNA，采用RT－PCR的方法研究不同组织中c-myc、ras、cyclinD1及bcl-2基因的表达。结果 正常口腔黏膜中未见c-myc、ras、cyclinD1及bcl-2基因表达；轻、中、重度异常增生白斑和鳞癌组织中c-myc、ras、cyclinD1及bcl-2基因表达显著增加。结论 c-myc、ras、cyclinD1及bcl-2基因的表达增加与口腔黏膜白斑及鳞癌的发生相关。
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| 关 键 词： | 口腔白斑 口腔鳞癌 癌基因 |
| 文章编号： | 1003-1634(2002)01-0049-03 |
Studies on the expression of different oncogene in oral leukoplakia and squamous cell carcinoma |
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| CHEN Lim ing,TIAN Mao neng,JIANG Kai ming,et al.. Studies on the expression of different oncogene in oral leukoplakia and squamous cell carcinoma[J]. Journal of Clinical Stomatology, 2002, 18(1): 49-51 |
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| Authors: | CHEN Lim ing TIAN Mao neng JIANG Kai ming et al. |
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| Affiliation: | CHEN Lim ing,TIAN Mao neng,JIANG Kai ming,et al. Department of Oral Medicine,Guiyang Stomatological Hospital,Guiyang 550002,China |
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| Abstract: | Objective To study on the expression of different oncogene in normal oral mucosa, oral leukoplakia and squamous cell carcinoma. Methods The tissue of oral mucosa was evaluated by HE stain. The expression of different oncogene in normal oral mucosa, oral leukoplakia and squamous cell carcinoma were evaluated by RT PCR analysis. Results No regulated expression of c myc, ras, cyclinD 1 and bcl 2 gene in normal oral mucosa. The over expression of c myc, ras, cyclinD 1 and bcl 2 gene can been found in oral leukoplakia and squamous cell carcinoma. Conclusion The over expression of c myc, ras, cyclinD 1 and bcl 2 gene were correlated with the occurrence of oral leukoplakia and squamous cell carcinoma. |
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| Keywords: | oral leukoplakia squamous cell carcinoma carcinoma oncogene |
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