Clonal identification of Burkitt's Lymphoma Arising from Lymphocyte-Predominant Hodgkin's Disease |
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| Authors: | Haruhiko,Yoshinaga ,Kazuteru,Ohashi ,Koh,Yamamoto ,Tohru,Miki ,Osamu,Miura ,Takako,Saito ,Takatoshi,Koyama ,Akira,Kanazawa ,Tetsuo,Nemoto ,Nobuyuki,Miyasaka ,Ryuichi,Kamiyama & Shinsaku,Hirosawa |
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| Affiliation: | First Department of Internal Medicine;, School of Allied Health Sciences;, Department of Pathology and Immunology;, Department of Pathology, Faculty of Medicine, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan |
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| Abstract: | The occurrence of large cell lymphomas subsequent to, or concurrent with, lymphocyte predominant Hodgkin's disease (LPHD) is a well-documented phenomenon. We present a case of Burkitt's lymphoma of the bladder, occurring after the successful treatment of LPHD of a cervical lymph node. To evaluate the clonal relationship of the two tumours, we amplified the complementarity-determining-region 3 of two samples from paraffin-embedded slides, using the polymerase chain reaction (PCR). The sequences of the PCR products showed 96% homology to each other. These results indicate that the malignant clone of Burkitt's lymphoma arose from the corresponding LPHD. |
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| Keywords: | Burkitt's lymphoma Hodgkin's disease clonality polymerase chain reaction |
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