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Risk of SARS-CoV-2 virus transmission from donor corneal tissue: A review
Authors:Anna K Salz  Manisha Acharya  Nicola Hofmann  Ilka Wittmershaus  Virender Sangwan  Martin Brgel  Umang Mathur
Institution:German Society for Tissue Transplantation (Deutsche Gesellschaft für Gewebetransplantation gGmbH, DGFG), Germany;1.Cornea and Refractive Surgery Services, Dr. Shroff''s Charity Eye Hospital (SCEH), New Delhi, India;2.Cornea and Ocular Surface Services, Dr. Shroff''s Charity Eye Hospital (SCEH), New Delhi, India
Abstract:Since the outbreak of respiratory coronavirus disease (COVID-19) caused by the coronavirus SARS-CoV-2, there is an ongoing discussion about whether the virus could be transmitted through corneal transplantation from donor to recipient. The purpose of this review was to summarize the current knowledge in the scientific community to provide aid in risk evaluation for potential virus transfer by corneal transplants. Literature was searched in PubMed.gov for relevant articles on coronavirus in conjunction with cornea processing, cornea transplantation and eye banking. Further, guidelines of health authorities and eye banking associations were reviewed. Studies have shown that SARS-CoV-2 RNA can be detected in ocular swabs and/or fluid of patients with COVID-19. However, the risk of SARS-CoV-2 virus transmission through these ocular tissues or fluid of patients is judged differently. To date, per literature and official guidelines, no evidence of viable virus in ocular tissue and no cases of transmission of SARS-CoV-2 via tissue preparations have been reported.
Keywords:Cornea  cornea processing  COVID-19  eye banking  SARS-CoV-2  virus transmission
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