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Angiotensin-converting enzyme gene polymorphism predicts the time-course of blood pressure response to angiotensin converting enzyme inhibition in the AASK trial |
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| Authors: | Bhatnagar Vibha O'Connor Daniel T Schork Nicholas J Salem Rany M Nievergelt Caroline M Rana Brinda K Smith Douglas W Bakris George L Middleton John P Norris Keith C Wright Jackson T Cheek Deanna Hiremath Leena Contreras Gabriel Appel Lawrence J Lipkowitz Michael S |
| Institution: | University of California San Diego, La Jolla, USA. vbhatnag@ucsd.edu |
| Abstract: | OBJECTIVE: It has yet to be determined whether genotyping at the angiotensin-converting enzyme (ACE) locus is predictive of blood pressure response to an ACE inhibitor. METHODS: Participants from the African American Study of Kidney Disease and Hypertension trial randomized to the ACE inhibitor ramipril (n = 347) were genotyped at three polymorphisms on ACE, just downstream from the ACE insertion/deletion polymorphism (Ins/Del): G12269A, C17888T, and G20037A. Time to reach target mean arterial pressure ( |
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