| 甜菊苷对麻醉大鼠血流动力学的影响 |
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| 引用本文： | 夏敬民,许德义,李芳. 甜菊苷对麻醉大鼠血流动力学的影响[J]. 医药导报, 2000, 19(2): 103-105 |
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| 作者姓名： | 夏敬民 许德义 李芳 |
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| 作者单位： | Xia Jinmin，Li Fang(Zhanjiang People's Centre Hospital，Zhanjiang 524037)，Xu Deyi(Department of Pharmacology，Nanjing Railway Medical College， Nanjing 210009)，Ding Yishang(Department of Pharmacology，Shihezi Medical College，Shihezi 832002) |
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| 基金项目： | 国家新药研究基金!(编号 :CND 90 1 2 ) |
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| 摘 要： | 目的：观察甜菊苷对麻醉大鼠血流动力学的影响。方法：Ｗｉｓｔａｒ Ｋｙｏｔｏ（ＷＫＹ（）大鼠及自发性高血压大鼠用戊巴比妥钠麻醉后，进行手术，术后１０ｍｉｎ给予甜菊苷药物试验。结果：２５，５０，１００ｍｇ／ｋｇ静脉注射可剂量依赖性地降低麻醉正常血压ＷＫＹ大鼠的收缩压和舒张压，并以降低舒张压的作用明显，同样可减慢心率，降低左心室内压最大上升速率和左心室内压对数值最大变化速率。结论：甜菊苷有较强而持久的降
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| 关 键 词： | 甜菊苷 哌唑嗪 血流动力学 麻醉 |
Effect of Stevioside on Hemodynamics in Anesthetized Rats |
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| Xia Jinmin,Li Fang. Effect of Stevioside on Hemodynamics in Anesthetized Rats[J]. Herald of Medicine, 2000, 19(2): 103-105 |
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| Authors: | Xia Jinmin Li Fang |
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| Abstract: | Objective:Effects of stevioside on hemodynamics of anesthetized rats were observed. Methods:Wistar Kyoto (WKY) rats and sponteneous hypertensive rats received operation after using pentobarbital anesthesia. Drug trial with stevioside was condacted 10 min after operation.Results:The normotensive WKY rats' systolic pressure and distolic pressure were declined in presenting dose dependent after given intraveneously 25, 50, and 100 mg/kg, respectively, especially the distolic pressure; while the heart rate, the maximal ascending rate of left ventricular pressure, and maximal changing rate of left ventricular logarithm value were decreased. Conclusion:Stevioside has a higher and persistant hypotensive effect, while heart rate and myocardial contraction can be inhibited. |
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| Keywords: | Stevioside Prazosin Hemodynamic Rat |
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