| c-IAP1在食管鳞癌中的表达及其对化疗敏感性的影响 |
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| 引用本文： | 许杨,刘芳,周兰萍,赵晓航. c-IAP1在食管鳞癌中的表达及其对化疗敏感性的影响[J]. 世界华人消化杂志, 2011, 0(11): 1138-1144 |
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| 作者姓名： | 许杨 刘芳 周兰萍 赵晓航 |
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| 作者单位： | 中国医学科学院北京协和医学院肿瘤研究所分子肿瘤学国家重点实验室;中国人民解放军海军总医院基础医学研究中心; |
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| 基金项目： | 国家自然科学基金资助项目,No.81021061;No.81071811;No.91029725; 国际科技合作与交流基金资助项目,No.2008DFA31130; 国家重点基础研究发展规划基金资助项目,No.2011CB910700~~ |
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| 摘 要： | 目的:探讨食管鳞癌细胞凋亡抑制蛋白1(c-IAP1)表达与化疗敏感性的相关性.方法:食管鳞癌组织芯片免疫组织化学染色,分析食管鳞癌组织及其配对癌旁食管上皮中c-IAP1的表达和定位及其与肿瘤,临床分级的关系.免疫印迹分析食管癌细胞C-IAP1和Smac表达,用RNA干扰技术敲降Smac表达,MTT法检测细胞对化疗药物敏...
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| 关 键 词： | 食管鳞状细胞癌 细胞凋亡抑制蛋白1 Smac |
c-IAP1 expression and tumor chemosensitivity in esophageal squamous cell carcinoma |
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| Yang Xu,Fang Liu,Lan-Ping Zhou,Xiao-Hang Zhao,State Key Laboratory of Molecular Oncology,Cancer Insti-tute,Hospital,Chinese Academy of Medical Sciences, Peking Union Medical College,Beijing ,China Xiao-Hang Zhao,Center for Basic Medical Sciences,Navy General Hospital of Chinese PLA,Beijing ,China. c-IAP1 expression and tumor chemosensitivity in esophageal squamous cell carcinoma[J]. World Chinese Journal of Digestology, 2011, 0(11): 1138-1144 |
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| Authors: | Yang Xu Fang Liu Lan-Ping Zhou Xiao-Hang Zhao State Key Laboratory of Molecular Oncology Cancer Insti-tute&Hospital Chinese Academy of Medical Sciences& Peking Union Medical College Beijing China Xiao-Hang Zhao Center for Basic Medical Sciences Navy General Hospital of Chinese PLA Beijing China |
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| Affiliation: | Yang Xu,Fang Liu,Lan-Ping Zhou,Xiao-Hang Zhao,State Key Laboratory of Molecular Oncology,Cancer Insti-tute&Hospital,Chinese Academy of Medical Sciences& Peking Union Medical College,Beijing 100021,China Xiao-Hang Zhao,Center for Basic Medical Sciences,Navy General Hospital of Chinese PLA,Beijing 100037,China |
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| Abstract: | AIM:To investigate the expression of cellular inhibitor of apoptosis protein 1(c-IAP1)in esophageal squamous cell carcinoma(ESCC)and to evaluate the correlation between c-IAP1 expression and chemosensitivity of ESCC cell lines.METHODS:Immunohistochemistry staining was performed to determine the expression of,c-IAP1 in ESCC on tissue microarray.The chisquare test was used to analyze the correlation between c-IAP1 expression and clinicopathologic parameters of ESCC.The expression of c-IAP1 and Smac in several... |
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| Keywords: | Esophageal squamous cell carcinoma Cellular inhibitor of apoptosis protein 1 Smac |
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