| hMLH1和RASSF1A在食管癌组织中的表达及其与患者预后的关系 |
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| 引用本文： | 蒲红伟,陈晓,李晓梅,卜晓红,龚晓瑾,张丽萍.hMLH1和RASSF1A在食管癌组织中的表达及其与患者预后的关系[J].世界华人消化杂志,2011(13):1347-1352. |
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| 作者姓名： | 蒲红伟 陈晓 李晓梅 卜晓红 龚晓瑾 张丽萍 |
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| 作者单位： | 新疆医科大学高职学院教学实验中心;新疆医科大学基础医学院病理学教研室;新疆医科大学第二附属医院病理科;新疆医科大学基础医学院生化教研室; |
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| 基金项目： | 新疆自治区自然科学基金项目资助,No.200821134~~ |
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| 摘 要： | 目的:探讨食管鳞癌组织中从hMLH1和RASSF1A基因表达及其对预后的影响.方法:采用原位杂交技术检测hMLH1基因、免疫组织化学法检测RASSF1A基因在60例食管鳞癌患者中的表达,应用Cox回归模型和Kaplan-Meier生存曲线分析其与患者预后的关系.结果:在食管鳞癌组织中hMLH1 mRNA表达显著低于正常...
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| 关 键 词： | 食管癌 hMLH1基因 RASSF1A基因 预后 |
Correlation between hMLH1 and RASSF1A expression and prognosis of esophageal carcinoma |
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| Hong-Wei Pu,Xiao-Mei Li,Higher Training College,Xinjiang Medical University,Urumqi ,Xinjiang Uygur Autonomous Region,China Xiao Chen,Xiao-Hong Bu.Correlation between hMLH1 and RASSF1A expression and prognosis of esophageal carcinoma[J].World Chinese Journal of Digestology,2011(13):1347-1352. |
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| Authors: | Hong-Wei Pu Xiao-Mei Li Higher Training College Xinjiang Medical University Urumqi Xinjiang Uygur Autonomous Region China Xiao Chen Xiao-Hong Bu |
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| Institution: | Hong-Wei Pu,Xiao-Mei Li,Higher Training College,Xinjiang Medical University,Urumqi 830011,Xinjiang Uygur Autonomous Region,China Xiao Chen,Xiao-Hong Bu,Department of Pathology,Preclinical College,China Xiao-Jin Gong,the Second Affiliated Hospital of Xinjiang Medical University,China Li-Ping Zhang,Department of Biochemistry,Xinjiang Medical Univ... |
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| Abstract: | AIM:To investigate the expression of human mutL homologue 1(hMLH1)and Ras association domain family 1A(RASSF1A)in esophageal squamous cell carcinoma(ESCC)and to analyze their prognostic value.METHODS:The expression of hMLH1 mRNA and RASSF1A protein in 60 specimens of esophageal cancer was detected by in situ hybridization(ISH)and immunohistochemistry,respectively.The relationship of hMLH1 and RASSF1A expression with ESCC prognosis was evaluated using Cox regression model and Kaplan-Meier survival curve anal... |
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| Keywords: | Esophageal squamous cell carcinoma Human mutl homologue 1 Ras association domain family 1A Prognosis |
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