| 食管鳞癌动物模型的研究进展 |
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| 引用本文： | 黄裔腾,殷秀凯,钟雪云,张灏. 食管鳞癌动物模型的研究进展[J]. 世界华人消化杂志, 2011, 0(16): 1704-1710 |
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| 作者姓名： | 黄裔腾 殷秀凯 钟雪云 张灏 |
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| 作者单位： | 汕头大学医学院肿瘤研究中心;暨南大学医学院病理学教研室;汕头大学医学院附属肿瘤医院中西医结合科; |
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| 基金项目： | 国家自然科学基金资助项目,No.81071736,No.30973508; 教育部高等学校博士点专项基金资助项目,No.20104402110005; 广东省高等学校人才引进资金资助项目,No.[2009]109; 汕头市科技计划重点基金资助项目,No.[2009]387~~ |
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| 摘 要： | 建立和应用真实模拟人类疾病的动物模型,从整体水平动态地揭示肿瘤发生机制,从而寻找防治对策和开发治疗新药,是成功开展转化医学研究的关键.食管癌是最高发的恶性肿瘤之一.由于相关活体动物模型研究和开发的相对滞后,对于食管鳞癌的病因、发病机制和相关分子通路缺乏全面系统深入的认识,直接导致无法有针对性地进行早期分子诊断标志物和有...
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| 关 键 词： | 食管鳞状细胞癌 基因工程小鼠 4-硝基喹啉-氧化物 转化 |
Advances in rodent models of human esophageal squamous cell carcinoma |
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| Yi-Teng Huang,Xiu-Kai Yin,Xue-Yun Zhong,Hao Zhang Yi-Teng Huang,Hao Zhang,Cancer Research Center,Shantou University Medical College,Shantou ,Guangdong Province,China Xue-Yun Zhong. Advances in rodent models of human esophageal squamous cell carcinoma[J]. World Chinese Journal of Digestology, 2011, 0(16): 1704-1710 |
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| Authors: | Yi-Teng Huang Xiu-Kai Yin Xue-Yun Zhong Hao Zhang Yi-Teng Huang Hao Zhang Cancer Research Center Shantou University Medical College Shantou Guangdong Province China Xue-Yun Zhong |
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| Affiliation: | Yi-Teng Huang,Xiu-Kai Yin,Xue-Yun Zhong,Hao Zhang Yi-Teng Huang,Hao Zhang,Cancer Research Center,Shantou University Medical College,Shantou 515041,Guangdong Province,China Xue-Yun Zhong,Department of Pathology,Medical College,Jinan University,Guangzhou 510632,China Hao Zhang,Department of Integrated Chinese and Western Medicine,the Affiliated Cancer Hospital of Shantou University Medical College,China |
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| Abstract: | Esophageal squamous cell carcinoma (ESCC) is a common form of malignant disease. Appropriate animal models recapitulating human cancers, which are powerful not only for the elucidation of in vivo process and relevantmechanisms of the diseases but also for the evaluation of efficacy and safety of new drugs and management concepts, are critical for the success of translational research. In this context, compared with other malignancies, the present situation for human ESCC that novel discoveries for either di... |
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| Keywords: | Esophageal squamous cell carcinoma Genetically engineered mice 4-nitroquinoline-1- oxide Transformation |
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