| Tim-3基因多态性与乙型肝炎病毒感染转归的相关性 |
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| 引用本文： | 崔明芳,郜玉峰,吕峰,李娜,张振华,李旭,苏菲.Tim-3基因多态性与乙型肝炎病毒感染转归的相关性[J].世界华人消化杂志,2011(14). |
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| 作者姓名： | 崔明芳 郜玉峰 吕峰 李娜 张振华 李旭 苏菲 |
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| 作者单位： | 安徽医科大学第一附属医院感染病科;安徽医科大学第二附属医院肝病科;六安市第一人民医院感染科; |
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| 基金项目： | 国家自然科学基金资助项目,No.81072342; 973前期专项课题基金资助项目,No.2009CB526411~~ |
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| 摘 要： | 目的:研究中国汉族人群T淋巴细胞免疫球蛋白黏蛋白-3(Tim-3)基因标签单核苷酸多态性(tagSNP)rs11741184C/G和rs13170556A/G位点多态性与乙型肝炎病毒(HBV)感染转归的关系.方法:采用SNaPshot技术检测996例慢性乙型肝炎患者及301例急性HBV感染自限性恢复患者Tim-3基因rs11741184和rs13170556tagSNP位点的多态性,计算其基因型和等位基因分布频率及单体型分布频率.结果:Tim-3基因tagSNPrs11741184位点基因型CC、CG、GG在急性乙型肝炎患者中的分布频率分别为84.39%(254/301)、15.28%(46/301)、0.33%(1/301),在慢性乙型肝炎组中分布频率分别为86.04%(857/996)、13.65%(136/996)、0.3%(3/996),两组比较无统计学差异;Tim-3基因tagSNP rs13170556基因型AA、GA、GG在急性乙型肝炎患者中的分布频率分别为68.77%(207/301)、28.57%(86/301)、2.66%(8/301),慢性乙型肝炎组患者中的分布频率分别为68.07%(6...
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| 关 键 词： | Tim-3基因 乙型肝炎病毒 单核苷酸多态性 单体型 |
Association between polymorphisms of the T cell immunoglobulin musin-3 gene and outcome of hepatitis B virus infection |
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| Ming-Fang Cui,Zhen-Hua Zhang,Na Li,Xu Li,Fei Su.Association between polymorphisms of the T cell immunoglobulin musin-3 gene and outcome of hepatitis B virus infection[J].World Chinese Journal of Digestology,2011(14). |
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| Authors: | Ming-Fang Cui Zhen-Hua Zhang Na Li Xu Li Fei Su |
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| Institution: | Ming-Fang Cui,Zhen-Hua Zhang,Na Li,Xu Li,Fei Su,Department of Infectious Diseases,the First Affiliated Hospital of Anhui Medical University,Hefei 230032,Anhui Province,China Yu-Feng Gao,Department of Hepatology,the Second Affil-iated Hospital of Anhui Medical University,Hefei 230601,China Feng Lv,the First Peo-ple's Hospital of Liu'an,Liu'an 237000,China |
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| Abstract: | AIM:To investigate the relationship between single nucleotide polymorphisms(SNPs)of the T cell immunoglobulin musin-3(Tim-3)gene and outcome of hepatitis B virus(HBV)infection in a Chinese Han population.METHODS:Two tagSNPs of the Tim-3 gene(rs11741184 and rs13170556)were genotyped,using the SNaPshot method in 996 patients with chronic HBV infection group and 301 patients with acute self-limiting HBV infection.The genotypes,allele frequencies and haplotypes of the two Tim-3 tagSNPs were compared between the... |
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| Keywords: | Tim-3 gene Hepatitis B virus Single nucleotide polymorphism Haplotype |
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