| 注射用尼扎替丁治疗消化性溃疡出血205例 |
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| 引用本文： | 王迎昕,陈锡美,朱风尚,韩英,王邦茂,周永宁,詹丽,王吉林. 注射用尼扎替丁治疗消化性溃疡出血205例[J]. 世界华人消化杂志, 2011, 0(18) |
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| 作者姓名： | 王迎昕 陈锡美 朱风尚 韩英 王邦茂 周永宁 詹丽 王吉林 |
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| 作者单位： | 同济大学附属同济医院;中国人民解放军第四军医大学第一附属医院;天津医科大学总医院;兰州大学第一医院;甘肃省人民医院;包头市中心医院; |
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| 摘 要： | 目的:研究注射用尼扎替丁治疗消化性溃疡出血的疗效及安全性.方法:采用多中心、随机、双盲、阳性药物平行对照研究.将2008-09/2009-12收集的205例经胃镜证实的消化性溃疡出血患者随机分为两组,试验组102例给予尼扎替丁0.1g,每日3次,对照组103例给予法莫替丁20mg,每日2次,连续5d.结果:共有201例患者可供疗效评价.试验组的临床显效率为85.0%,总有效率为99.0%,对照组的临床显效率为82.2%,总有效率为98.0%,两组间差异无统计学意义(P>0.05).两组不良反应主要为白细胞减少、转氨酶轻度升高和贫血(P>0.05).结论:注射用尼扎替丁是治疗消化性溃疡合并上消化系出血有效且安全的药物.
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| 关 键 词： | 消化性溃疡 出血 尼扎替丁 |
A multi-center clinical trial to evaluate the efficacy and safety of intravenous nizatidine in the management of peptic ulcer bleeding |
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| Ying-Xin Wang,Xi-Mei Chen,Feng-Shang Zhu,Tongji Hospital Affiliated to Tongji University,Shanghai ,China Ying Han,the First Affiliated Hospital of Fourth Military Medical University of Chinese PLA,Xi'an ,Shaanxi Province,China Bang-Mao Wang,Tianjin Medical University General Hospital,Tianjin ,China Yong-Ning Zhou,the First Hospital of Lanzhou University,Lanzhou ,Gansu Province,China Li Zhan,the People's Hospital of Gansu Province,China Ji-Lin Wang,the Ce.... A multi-center clinical trial to evaluate the efficacy and safety of intravenous nizatidine in the management of peptic ulcer bleeding[J]. World Chinese Journal of Digestology, 2011, 0(18) |
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| Authors: | Ying-Xin Wang Xi-Mei Chen Feng-Shang Zhu Tongji Hospital Affiliated to Tongji University Shanghai China Ying Han the First Affiliated Hospital of Fourth Military Medical University of Chinese PLA Xi'an Shaanxi Province China Bang-Mao Wang Tianjin Medical University General Hospital Tianjin China Yong-Ning Zhou the First Hospital of Lanzhou University Lanzhou Gansu Province China Li Zhan the People's Hospital of Gansu Province China Ji-Lin Wang the Ce... |
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| Affiliation: | Ying-Xin Wang,Xi-Mei Chen,Feng-Shang Zhu,Tongji Hospital Affiliated to Tongji University,Shanghai 200065,China Ying Han,the First Affiliated Hospital of Fourth Military Medical University of Chinese PLA,Xi'an 710043,Shaanxi Province,China Bang-Mao Wang,Tianjin Medical University General Hospital,Tianjin 300052,China Yong-Ning Zhou,the First Hospital of Lanzhou University,Lanzhou 730000,Gansu Province,China Li Zhan,the People's Hospital of Gansu Province,China Ji-Lin Wang,the Ce... |
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| Abstract: | AIM:To evaluate the safety and safety of intravenous nizatidine in the management of peptic ulcer bleeding.METHODS:A muti-center,randomized,parallel-controlled clinical trial was conducted in 205 patients with endoscopically proved peptic ulcer bleeding.The patients were randomly divided into nizatidine group(n = 102) and control group(n = 103).Patients in the nizatidine group were intravenously given nizatidine 0.1 g three times daily for 5 days,while those in the control group were intravenously given fam... |
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| Keywords: | Peptic ulcer Bleeding Nizatidine |
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