| 弹簧幽门植入术结合高盐热淀粉糊灌胃诱导大鼠萎缩性胃炎模型的方法及评价 |
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| 引用本文： | 史瑞,李晓红,方蕾,李健,蔡大勇,李军祥,刘礼剑.弹簧幽门植入术结合高盐热淀粉糊灌胃诱导大鼠萎缩性胃炎模型的方法及评价[J].世界华人消化杂志,2011(10):1001-1008. |
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| 作者姓名： | 史瑞 李晓红 方蕾 李健 蔡大勇 李军祥 刘礼剑 |
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| 作者单位： | 北京中医药大学东方医院;中国医学科学院中国协和医科大学药用植物研究所;北京中医药大学基础医学院组织与胚胎学教研室; |
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| 基金项目： | 国家自然科学基金资助项目,No.30973741~~ |
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| 摘 要： | 目的:建立及改良符合我国萎缩性胃炎(atrophicgastritis,AG)发病特点的大鼠模型并对模型进行评价.方法:健康、清洁级、♂、Wistar大鼠51只,随机分为空白对照组(10只),假手术组(10只),造模2 mo组(10只),造模3 mo组(10只),造模4 mo组(11只),空白组大鼠常规饲养,待造模组大...
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| 关 键 词： | 萎缩性胃炎 模型 大鼠 前列腺素E2 胃泌素 |
Development of a rat model of atrophic gastritis by implantation of a spring into the pylorus in combination with intragastric administration of hot salty starch paste |
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| Rui Shi,Xiao-Hong Li,Jun-Xiang Li,Li-Jian Liu,Dongfang Hospital,Beijing University of Chinese Medicine,Beijing ,China Lei Fang,Da-Yong Cai.Development of a rat model of atrophic gastritis by implantation of a spring into the pylorus in combination with intragastric administration of hot salty starch paste[J].World Chinese Journal of Digestology,2011(10):1001-1008. |
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| Authors: | Rui Shi Xiao-Hong Li Jun-Xiang Li Li-Jian Liu Dongfang Hospital Beijing University of Chinese Medicine Beijing China Lei Fang Da-Yong Cai |
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| Institution: | Rui Shi,Xiao-Hong Li,Jun-Xiang Li,Li-Jian Liu,Dongfang Hospital,Beijing University of Chinese Medicine,Beijing 100078,China Lei Fang,Da-Yong Cai,Institute of Medicinal Plant Development,Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing 100193,China Jian Li,Department of Histology,Beijing 100029,China |
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| Abstract: | AIM:To establish a novel rat model of atrophic gastritis according to the characteristics of the disease in Chinese patients.METHODS:Fifty-one healthy male Wistar rats were randomized into five groups:control group(n=10),sham operation group(n=10),2-mo model group(n=10),3-mo model group (n=10),and 4-mo model group(n=11).Atrophic gastritis was induced in rats of the three model groups by implanting a spring into the pylorus and intragastrically administering hot salty starch paste.The control group did not u... |
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| Keywords: | Atrophic gastritis Model Rat Prostaglandin E2 Gastrin |
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