| Akt的活化对胃癌血管新生的促进作用 |
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| 引用本文： | 周晓东,陈红霞,关润年,吕农华. Akt的活化对胃癌血管新生的促进作用[J]. 世界华人消化杂志, 2011, 0(7): 744-748 |
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| 作者姓名： | 周晓东 陈红霞 关润年 吕农华 |
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| 作者单位： | 南昌大学第一附属医院消化内科;南昌大学第一附属医院妇产科; |
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| 基金项目： | 江西省自然科学基金资助项目,No. 2007GQY1167~~ |
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| 摘 要： | 目的:研究Akt在胃癌及癌旁正常组织中的表达、活化状况及其与胃癌血管新生的关系.方法:收集手术切除的胃癌及相应的癌旁正常组织标本48例.采用Western blot法检测20例新鲜胃癌及癌旁组织Akt和磷酸化Akt(pAkt)蛋白的表达.以免疫组织化学法检测pAkt蛋白在48例胃癌和癌旁正常组织的表达以及血管内皮生长因...
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| 关 键 词： | 胃癌 蛋白激酶B 血管内皮生长因子 蛋白免疫印迹 |
Akt activation promotes angiogenesis in gastric cancer |
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| Xiao-Dong Zhou,Run-Nian Guan,Nong-Hua Lv. Akt activation promotes angiogenesis in gastric cancer[J]. World Chinese Journal of Digestology, 2011, 0(7): 744-748 |
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| Authors: | Xiao-Dong Zhou Run-Nian Guan Nong-Hua Lv |
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| Affiliation: | Xiao-Dong Zhou,Run-Nian Guan,Nong-Hua Lv,Department of Gastroenterology,the First Affiliated Hospital of Nanchang University,Nanchang 330006,Jiangxi Province,China Hong-Xia Chen,Department of Obstetrics and Gynaecology,China |
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| Abstract: | AIM:To determine the expression and activation of Akt in gastric cancer and to investigate the role of Akt activation in tumor angiogenesis in gastric cancer.METHODS:Forty-eight fresh gastric adenocarcinoma tissue samples and matched normal gastric mucosal samples were collected surgically from patients with gastric cancer and immediately frozen in liquid nitrogen.The expression levels of Akt and phosphorylated Akt(pAkt) in the above tissue samples were measured by Western blot.Immunohistochemistry was cond... |
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| Keywords: | Gastric cancer Protein kinase B Vascular endothelial growth factor Western blot |
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