| PNPLA3基因在非酒精性脂肪性肝病中的作用 |
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| 引用本文： | 李冬阳,林连捷,郑长青.PNPLA3基因在非酒精性脂肪性肝病中的作用[J].世界华人消化杂志,2011(17):1796-1801. |
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| 作者姓名： | 李冬阳 林连捷 郑长青 |
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| 作者单位： | 中国医科大学附属盛京医院;中国医科大学附属盛京医院消化内科; |
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| 基金项目： | 辽宁省科学技术基金资助项目,No.2010225008; 辽宁省博士科研启动基金资助项目,No.20081048; 沈阳市科学技术基金资助项目,No.F10-205-1-17~~ |
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| 摘 要： | 非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD) 在世界范围内发病率成日益上升趋势,其相关基因研究对完善其致病机制,补充其治疗方案及改善预后至关重要.目前,国内外多项实验证实含patatin 样磷脂酶域3(PNPLA3) 基因突变与NAFLD 密切相关,考虑其与肝脏脂...
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| 关 键 词： | 含patatin样磷脂酶域3 脂肪滋养蛋白 非酒精性脂肪性肝病 基因突变 |
Advances in understanding the role of PNPLA3 in the pathogenesis of non-alcoholic fatty liver disease |
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| Dong-Yang Li,Shengjing Hospital of China Medical University,Shenyang ,Liaoning Province,China Lian-Jie Lin,Chang-Qing Zheng.Advances in understanding the role of PNPLA3 in the pathogenesis of non-alcoholic fatty liver disease[J].World Chinese Journal of Digestology,2011(17):1796-1801. |
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| Authors: | Dong-Yang Li Shengjing Hospital of China Medical University Shenyang Liaoning Province China Lian-Jie Lin Chang-Qing Zheng |
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| Institution: | Dong-Yang Li,Shengjing Hospital of China Medical University,Shenyang 110004,Liaoning Province,China Lian-Jie Lin,Chang-Qing Zheng,Department of Gastroenterology,China |
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| Abstract: | The incidence of non-alcoholic fatty liver disease (NAFLD) is rising worldwide. Investigation of genes involved in the pathogenesis of NAFLD is significant for replenishing treatment scheme and improving prognosis. Multiple studies have established a correlation between patatin-like phospholipase domain-containing 3 (PNPLA3) gene mutation and the pathogenesis of NAFLD, suggesting that PNPLA3 may affect lipid metabolism. However, the precise mechanism remains to be elucidated. Some researchers believed that ... |
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| Keywords: | Patatin-like phospholipase domaincontaining 3 Adiponectin Non-alcoholic fatty liver disease Gene mutation |
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