| TRAF4在胃癌组织中的表达及意义 |
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| 引用本文： | 刘辉琦,李菊英,刘杰,王生兰.TRAF4在胃癌组织中的表达及意义[J].世界华人消化杂志,2011(4). |
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| 作者姓名： | 刘辉琦 李菊英 刘杰 王生兰 |
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| 作者单位： | 青海大学医学院病理生理教研室;青海大学医学院病理教研室; |
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| 基金项目： | 青海大学医学院中青年科技基金资助项目,No.qy-2008-03~~ |
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| 摘 要： | 目的:探讨肿瘤坏死因子受体相关因子4(TRAF4)在胃癌发生、发展中的作用.方法:应用组织芯片采用免疫组织化学法检测10例正常胃组织、45例胃癌及癌旁组织中TRAF4的表达,TUNEL法检测TRAF4阳性胃癌及正常胃组织中细胞凋亡.结果:TRAF4在正常胃组织中呈浆、核阳性表达.其浆阳性率在正常胃组织(80%)、不典型增生(93.3%)和胃癌(95.6%)中逐渐增高,但差异无统计学意义.而核阳性率在正常胃组织中高于胃癌(70.0%vs35.6%,P<0.05),在高分化胃癌中高于低分化胃癌(71.4%vs26.1%,P<0.05),在无淋巴转移胃癌中高于伴有淋巴转移(52.4%vs20.8%,P<0.05).TRAF4表达阳性正常胃组织细胞凋亡百分率高于胃癌组织(75vs37.2,P<0.05).结论:TRAF4在胃癌中具有较低核表达,且其核表达与胃癌分化程度呈正相关,与胃癌转移呈负相关,同时可能抑制胃癌凋亡.
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| 关 键 词： | 胃癌 肿瘤坏死因子受体相关因子-4 免疫组织化学 凋亡 |
Significance of TRAF4 protein expression in gastric carcinoma |
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| Hui-Qi Liu,Jie Liu,Sheng-Lan Wang.Significance of TRAF4 protein expression in gastric carcinoma[J].World Chinese Journal of Digestology,2011(4). |
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| Authors: | Hui-Qi Liu Jie Liu Sheng-Lan Wang |
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| Institution: | Hui-Qi Liu,Jie Liu,Sheng-Lan Wang,Department of Pathophysiology,Medical College of Qinghai University,Xining 810001,Qinghai Province,China Ju-Ying Li,Department of Pathology,China |
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| Abstract: | AIM:To investigate the correlation between the expression of tumor necrosis factor receptorassociated factor 4(TRAF4) protein and tumor onset and evolution in gastric carcinoma.METHODS:Tissue microarray was used to detect the expression of TRAF4 in 45 gastric carcinoma specimens,45 tumor-adjacent tissue specimens,and 10 normal gastric tissue specimens.Cell apoptosis in TRAF4-positive gastric carcinoma specimens and normal gastric tissue specimens was detected by TUNEL assay.RESULTS:TRAF4 was expressed in bo... |
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| Keywords: | Gastric carcinoma Tumor necrosis factor receptor-associated factor 4 Immunohistochemistry Apoptosis |
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