| 血清胃蛋白酶原检测在胃癌及其癌前病变筛查中的价值 |
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| 引用本文： | 张志镒,王贵齐,吴正奇,卢林芝,贺舜,赵光源,刘金殿.血清胃蛋白酶原检测在胃癌及其癌前病变筛查中的价值[J].世界华人消化杂志,2011(14). |
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| 作者姓名： | 张志镒 王贵齐 吴正奇 卢林芝 贺舜 赵光源 刘金殿 |
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| 作者单位： | 甘肃省武威肿瘤医院;中国医学科学院肿瘤医院; |
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| 摘 要： | 目的:探讨血清胃蛋白酶原(PG)检测在胃癌及其癌前病变筛查中的价值.方法:在胃癌高发区对35岁以上无症状、有胃病史及胃癌家族史者进行内镜筛查.同时采用免疫比浊法测定受检者血清PG水平,结合内镜活检和病理检查结果,对比分析接受受检者血清PGⅠ、PGⅡ水平和PGⅠ/Ⅱ值与胃癌及其癌前病变的关系.结果:内镜筛查共计918例,其中PG阴性718例(78.21%);阳性200例(21.79%),阳性人群中以40-60岁最多139例(69.50%);总体胃癌检出率7/918(0.76%),早期胃癌检出率为5/7(71.43%),进展期为2/7(28.57%);PG阳性癌检出率3/200(1.50%),高级别上皮内瘤变检出率2/200(1.00%),低级别上皮内瘤变检出率23/200(11.50%);PG阴性癌检出率4/718(0.56%),高级别上皮内瘤变检出率0/718(00.00%),低级别上皮内瘤变检出率54/718(7.52%);PG阳性与PG阴性之间胃癌及其癌前病变检出率有显著性差异(P<0.01).PG阳性中早期胃癌检出率为2/3(66.67%),胃癌诊断的敏感性42.86%,特异性78.38%.结论:以血清...
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| 关 键 词： | 胃蛋白酶原类 胃肿瘤 癌前病变 病理学 |
Value of serum pepsinogens in the screening of gastric carcinoma and precancerous lesions |
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| Zhi-Yi Zhang,Zheng-Qi Wu,Lin-Zhi Lu,Guang-Yuan Zhao,Jin-Dian Liu,Wuwei Tumor Hospital,Wuwei ,Gansu Province,China Gui-Qi Wang,Shun He,Cancer Institute , Hospital,Chinese Academy of Medical Sciences,Beijing ,China.Value of serum pepsinogens in the screening of gastric carcinoma and precancerous lesions[J].World Chinese Journal of Digestology,2011(14). |
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| Authors: | Zhi-Yi Zhang Zheng-Qi Wu Lin-Zhi Lu Guang-Yuan Zhao Jin-Dian Liu Wuwei Tumor Hospital Wuwei Gansu Province China Gui-Qi Wang Shun He Cancer Institute Hospital Chinese Academy of Medical Sciences Beijing China |
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| Institution: | Zhi-Yi Zhang,Zheng-Qi Wu,Lin-Zhi Lu,Guang-Yuan Zhao,Jin-Dian Liu,Wuwei Tumor Hospital,Wuwei 733000,Gansu Province,China Gui-Qi Wang,Shun He,Cancer Institute and Hospital,Chinese Academy of Medical Sciences,Beijing 100021,China |
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| Abstract: | AIM:To evaluate the value of serum pepsinogens(PG)in the screening of gastric carcinoma and precancerous lesions.METHODS:We chose asymptomatic people aged over 35 years who had a history of gastric diseases or a family history of gastric carcinoma and came from a high-risk area for gastric carcinoma to measure serum PG levels by immunoturbidimetric assay and to conduct endoscopic biopsy and pathological examination.The relationship of serum levels of PGI,PGII,and PGI/II ratio with the incidence of gastric c... |
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| Keywords: | Pepsinogen Stomach neoplasms Pre-cancerous lesions Pathology |
| 本文献已被 CNKI 等数据库收录！ |
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