| P-gp和ABCG2在食管鳞状细胞癌中的表达及临床病理意义 |
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| 引用本文： | 龚晓瑾,古力巴哈尔·阿不力米提,蒲红伟,陈晓. P-gp和ABCG2在食管鳞状细胞癌中的表达及临床病理意义[J]. 世界华人消化杂志, 2011, 0(7): 728-733 |
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| 作者姓名： | 龚晓瑾 古力巴哈尔·阿不力米提 蒲红伟 陈晓 |
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| 作者单位： | 新疆医科大学第二附属医院病理科;新疆医科大学基础医学院病理学教研室; |
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| 基金项目： | 新疆地方病分子生物学重点实验室开放课题基金资助项目No. XJDX0208-2006-09~~ |
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| 摘 要： | 目的:研究肿瘤耐药相关基因P-gp和ABCG2在食管鳞状细胞癌组织中的表达及其临床病理特征和预后的关系.方法:应用免疫组织化学SP法检测食管鳞状细胞癌患者76例及正常食管黏膜30例,观察肿瘤耐药相关基因P-gp和ABCG2的表达,同时回顾性研究了这些表达与食管鳞状细胞癌发生、浸润及转移等临床病理学参数的关系.结果:(1...
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| 关 键 词： | 食管鳞状细胞癌 P-糖蛋白 三磷酸腺苷结合转运蛋白G超家族成员2 |
Clinicopathologic significance of expression of P-gp and ABCG2 in esophageal squamous cell carcinoma |
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| Affiliation: | Xiao-Jin Gong,Gulibahaer·Abulimiti,Department of Pathology,the Second Affiliated Hospital of Xinjiang Medical University,Urumqi 830063,Xinjiang Uygur Autonomous Region,China Hong-Wei Pu,Xiao Chen,Xinjiang Medical University,Urumqi 830011,China |
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| Abstract: | AIM:To investigate the expression of P-glycoprotein(P-gp) and ATP-binding cassette superfamily G member 2(ABCG2) in esophageal squamous cell carcinoma(ESCC) and to analyze their clinicopathologic significance.METHODS:Immunohistochemistry was used to detect the expression of P-gp and ABCG2 in 76 cases of ESCC and in 30 cases of normal esophageal tissue.The relationship of P-gp and ABCG2 expression with clinicopathologic parameters of ESCC was then analyzed.RESULTS:The positive rates of P-gp and ABCG2 express... |
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| Keywords: | Esophageal squamous cell carcinoma P-glycoprotein ATP-binding cassette superfamily G member 2 |
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