| P53和Ki67在胃癌中的表达及其临床意义 |
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| 引用本文： | 刘伟,余英豪,欧阳学农,王烈,武一曼,陈娟,熊喜生. P53和Ki67在胃癌中的表达及其临床意义[J]. 世界华人消化杂志, 2011, 0(4) |
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| 作者姓名： | 刘伟 余英豪 欧阳学农 王烈 武一曼 陈娟 熊喜生 |
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| 作者单位： | 中国人民解放军南京军区福州总医院病理科;中国人民解放军南京军区福州总医院肿瘤科;中国人民解放军南京军区福州总医院普外科;福建中医药大学病理教研室; |
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| 摘 要： | 目的:探讨胃癌中P53和Ki67蛋白表达与临床病理参数的相关性及其临床意义.方法:收集在中国人民解放军南京军区福州总医院手术切除的胃癌组织标本1107例,采用EliVisionTM plus免疫组织化学染色方法检测其中临床资料完整的775例胃腺癌标本中Ki67和P53蛋白表达.结果:在775例胃腺癌组织标本中,P53和Ki67蛋白的阳性表达率分别为46.84%和78.97%,在非肿瘤性胃黏膜中均未见其阳性表达;P53和Ki67蛋白表达,在肠型胃癌中显著高于弥漫型胃癌(54.7%vs38.0%;86.0%vs70.0%,均P<0.05),高中分化胃癌显著高于低分化胃癌(54.7%vs35.4%;87.0%vs67.2%,均P<0.05);P53蛋白表达在胃食管连接部胃癌和无远处转移的胃癌中显著高于胃部胃癌和有远处转移的胃癌(53.7%vs41.9%;49.0%vs30.3%,均P<0.05);Ki67蛋白表达随着浸润深度的增加而增高(80.3%vs60.4%,P<0.05),有淋巴结转移的患者显著高于无淋巴结转移的患者(81.4%vs72.6%,P<0.05).结论:联合检测P53和Ki67蛋白表达有助于阐释胃...
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| 关 键 词： | 胃癌 P53 Ki67 表皮生长因子受体-2 免疫组织化学 临床病理参数 |
Clinical significance of P53 and Ki67 expression in gastric cancer |
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| Wei Liu,Ying-Hao Yu,Juan Chen,Xi-Sheng Xiong. Clinical significance of P53 and Ki67 expression in gastric cancer[J]. World Chinese Journal of Digestology, 2011, 0(4) |
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| Authors: | Wei Liu Ying-Hao Yu Juan Chen Xi-Sheng Xiong |
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| Affiliation: | Wei Liu,Ying-Hao Yu,Juan Chen,Xi-Sheng Xiong,Department of Pathology,Fuzhou General Hospital of Nanjing Military Command of Chinese PLA,Fuzhou 350025,Fujian Province,China Xue-Nong Ouyang,Department of Oncology,China Lie Wang,Department of General Surgery,China Yi-Man Wu,Fujian University of T... |
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| Abstract: | AIM:To investigate the correlation of P53 and Ki67 protein expression with the clinicopathological parameters in gastric cancer.METHODS:A total of 1 107 surgical specimens of gastric cancer were collected from the Fuzhou General Hospital of Nanjing Military Command,The expression of P53 and Ki67 was examined by immunohistochemistry in 775 gastric cancer specimens taken from patients with complete clinical data.RESULTS:The positive rates of P53 and Ki67 protein expression were 46.84%and 78.97%,respectively.H... |
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| Keywords: | Gastric cancer P53 Ki67 Her-2 Immunohistochemistry Clinicopathological parameter |
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