| 危险信号分子与原发性肝癌的研究进展 |
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| 引用本文： | 周蓉蓉,范学工. 危险信号分子与原发性肝癌的研究进展[J]. 世界华人消化杂志, 2011, 0(13): 1326-1330 |
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| 作者姓名： | 周蓉蓉 范学工 |
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| 作者单位： | 中南大学湘雅医院感染病科; |
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| 基金项目： | 国家自然科学基金资助项目,No.30972621~~ |
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| 摘 要： | 危险信号分子,是一大类细胞结构蛋白,病理情况下释放到细胞外,通过启动和介导炎症反应,传递着细胞损伤的危险信号.以HMGB1、HSPs和S100为代表的危险信号分子,在肝脏慢性炎症和肿瘤形成的微环境中持续存在,在原发性肝癌形成和进展过程中发挥着重要的作用.危险信号分子可以成为新的预测和监测原发性肝癌发生、转移和复发的标志...
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| 关 键 词： | 危险信号分子 慢性炎症 原发性肝癌 |
Role of alarmins in the pathogenesis of primary hepatic carcinoma |
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| Rong-Rong Zhou,Xue-Gong Fan. Role of alarmins in the pathogenesis of primary hepatic carcinoma[J]. World Chinese Journal of Digestology, 2011, 0(13): 1326-1330 |
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| Authors: | Rong-Rong Zhou Xue-Gong Fan |
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| Affiliation: | Rong-Rong Zhou,Xue-Gong Fan,Department of Infectious Diseases,Xiangya Hospital of Central South University,Changsha 410008,Hunan Province,China |
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| Abstract: | Alarmins are a kind of constitutive cellular proteins which are released extracellularly under pathological conditions to signal danger to the host by triggering and mediating inflammatory responses.Persistent release of alarmins(e.g.,HMBG1,HSPs and S100)during chronic liver inflammation and in tumor microenvironments plays an important role in the development and progression of liver carcinoma.Alarmins might become novel markers for predicting and monitoring carcinogenesis,metastasis and recurrence of live... |
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| Keywords: | Alarmins Chronic inflammation Primary hepatic carcinoma |
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